Case Report: Molecular Analyses of Cell-Cycle-Related Genes in Cortical Brain Tissue of a Patient with Rasmussen Encephalitis

Rasmussen's encephalitis (RE) stands as a rare neurological disorder marked by progressive cerebral hemiatrophy and epilepsy resistant to medical treatment. Despite extensive study, the primary cause of RE remains elusive, while its histopathological features encompass cortical inflammation, ne...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-08, Vol.25 (15), p.8487
Main Authors: Gonçalves, João Ismael Budelon, de Castro, Vinicius Rosa, Martins, William Alves, Xavier, Fernando Antonio Costa, Da Costa, Jaderson Costa, Neto, Eliseu Paglioli, Palmini, André, Marinowic, Daniel Rodrigo
Format: Article
Language:English
Subjects:
Brain
Brain - metabolism
Brain - pathology
Brain-derived neurotrophic factor
Brain-Derived Neurotrophic Factor - genetics
Brain-Derived Neurotrophic Factor - metabolism
Case reports
Case studies
Cell cycle
Cell Cycle - genetics
Cell Cycle Proteins - genetics
Cell Cycle Proteins - metabolism
Cerebral Cortex - metabolism
Cerebral Cortex - pathology
Convulsions & seizures
Cytokines
Development and progression
Encephalitis
Encephalitis - genetics
Encephalitis - metabolism
Encephalitis - pathology
Epilepsy
Female
Genes
Humans
Inflammation
Lacosamide
Male
Medical research
Medicine, Experimental
Nervous system diseases
Neurons
Neurophysiology
Proteins
Seizures (Medicine)
Surgery
Tumor Necrosis Factor-alpha - genetics
Tumor Necrosis Factor-alpha - metabolism
Tumor necrosis factor-TNF
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Description
Summary:Rasmussen's encephalitis (RE) stands as a rare neurological disorder marked by progressive cerebral hemiatrophy and epilepsy resistant to medical treatment. Despite extensive study, the primary cause of RE remains elusive, while its histopathological features encompass cortical inflammation, neuronal degeneration, and gliosis. The underlying molecular mechanisms driving disease progression remain largely unexplored. In this case study, we present a patient with RE who underwent hemispherotomy and has remained seizure-free for over six months, experiencing gradual motor improvement. Furthermore, we conducted molecular analysis on the excised brain tissue, unveiling a decrease in the expression of cell-cycle-associated genes coupled with elevated levels of BDNF and TNF-α proteins. These findings suggest the potential involvement of cell cycle regulators in the progression of RE.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25158487