Level of Cytokines and C3 Complement in the Blood of Rats under Conditions of Chronic Unpredictable Stress of Different Durations

The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamic...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2024-07, Vol.177 (3), p.297-300
Main Authors: Skripkina, D. V., Abramova, A. Yu, Shoibonov, B. B., Alekseeva, I. V., Nikenina, E. V., Pertsov, S. S.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Blood levels
Cell Biology
Complement C3 - metabolism
Complement component C3
Complement system
Cytokines
Cytokines - blood
Immune response (humoral)
Interleukin 10
Interleukin 4
Interleukin-10 - blood
Interleukin-4 - blood
Internal Medicine
Laboratory Medicine
Lysis
Male
Pathology
Rats
Rats, Wistar
Statistical analysis
Stress, Physiological - immunology
Stress, Psychological - blood
Stress, Psychological - immunology
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Summary:The parameters of the cytokine profile and functional activity of the complement system in the blood of rats were studied during different time periods of chronic unpredictable mild stress using a model of sequentially alternating low-intensity stress effects for 1, 2, 3, and 4 weeks. In the dynamics of observation, a general tendency towards multidirectional fluctuations in the concentration of cytokines was revealed: an increase in IL-10, but a decrease in IL-4 in comparison with the control. Statistically significant changes in the level of IL-10 were noted after 2, 3, and 4 weeks, IL-4 — after 2 and 4 weeks of stress loads. The percentage of lysis of the C3 component in rats gradually increased by the 2nd week of chronic stress, but then decreased and practically did not differ from the control values (intact animals) by the end of the study. These results illustrate the specificity of changes in the indicators of the C component of the complement system and the cytokine profile of the blood reflecting activity of the cellular and humoral components of the immune response in rats exposed to repeated stress factors of different origins and duration.
ISSN:0007-4888
1573-8221
1573-8221
DOI:10.1007/s10517-024-06177-x