Postoperative radiotherapy in women with early operable breast cancer (Scottish Breast Conservation Trial): 30-year update of a randomised, controlled, phase 3 trial

Breast-conserving surgery, adjuvant systemic therapy, and radiotherapy are the standard of care for most women with early breast cancer. There are few reports of clinical outcomes beyond the first decade of follow-up of randomised trials comparing breast-conserving surgery with or without radiothera...

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Bibliographic Details
Published in:The lancet oncology 2024-09, Vol.25 (9), p.1213-1221
Main Authors: Williams, Linda J, Kunkler, Ian H, Taylor, Karen J, Dunlop, Joanna, Piper, Tammy, Caldwell, Jacqueline, Jack, Wilma, Loane, Joseph F, Elder, Kenneth, Bartlett, John M S, Dixon, J Michael, Cameron, David A
Format: Article
Language:English
Subjects:
5-Fluorouracil
Adult
Aged
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Breast cancer
Breast Neoplasms - mortality
Breast Neoplasms - pathology
Breast Neoplasms - radiotherapy
Breast Neoplasms - surgery
Breast Neoplasms - therapy
Breast surgery
Cancer therapies
Chemotherapy
Chemotherapy, Adjuvant
Clinical trials
Collaboration
Cyclophosphamide
Cyclophosphamide - administration & dosage
Cyclophosphamide - therapeutic use
Data collection
Disease-Free Survival
Estrogen receptors
Female
Fluorouracil - administration & dosage
Fluorouracil - therapeutic use
Humans
Lumpectomy
Mastectomy, Segmental
Menstruation
Methotrexate
Methotrexate - administration & dosage
Methotrexate - therapeutic use
Middle Aged
Neoplasm Recurrence, Local - pathology
Neoplasm Staging
Patients
Proteins
Radiation therapy
Radiotherapy, Adjuvant
Receptors, Estrogen - metabolism
Scotland
Stratification
Surgery
Survival
Tamoxifen - therapeutic use
Treatment Outcome
Tumors
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Summary:Breast-conserving surgery, adjuvant systemic therapy, and radiotherapy are the standard of care for most women with early breast cancer. There are few reports of clinical outcomes beyond the first decade of follow-up of randomised trials comparing breast-conserving surgery with or without radiotherapy. We present a 30-year update of the Scottish Breast Conservation Trial. In this randomised, controlled, phase 3 trial across 14 hospitals in Scotland, women aged younger than 70 years with early breast cancer (tumours ≤4 cm [T1 or T2 and N0 or N1]) were included. They underwent breast-conserving surgery (1 cm margin) with axillary node sampling or clearance. Oestrogen receptor (ER)-rich patients (≥20 fmol/mg protein) received 20 mg oral tamoxifen daily for 5 years. ER-poor patients (
ISSN:1470-2045
1474-5488
1474-5488
DOI:10.1016/S1470-2045(24)00347-4