Burden of 30 cancers among men: Global statistics in 2022 and projections for 2050 using population‐based estimates

• Published in: Cancer 2024-11, Vol.130 (21), p.3708-3723
• Main Authors: Bizuayehu, Habtamu Mellie, Dadi, Abel F., Ahmed, Kedir Y., Tegegne, Teketo Kassaw, Hassen, Tahir Ahmed, Kibret, Getiye Dejenu, Ketema, Daniel Bekele, Bore, Meless G., Thapa, Subash, Odo, Daniel Bogale, Kassa, Zemenu Y., Shifti, Desalegn Markos, Amsalu, Erkihun, Sarich, Peter, Venchiarutti, Rebecca L., Melaku, Yohannes Adama, Kibret, Kelemu Tilahun, Habte, Aklilu, Mefsin, Yonatan M., Seid, Abdulbasit, Belachew, Sewunet Admasu
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age; Aged; Aged, 80 and over; age‐standardized incidence rates; age‐standardized mortality rates; burden and projection; Cancer; Estimates; Fatalities; Global Health - statistics & numerical data; Human Development Index; Humans; Incidence; Male; men; Middle Aged; Mortality; mortality‐to‐incidence ratio; Neoplasms - epidemiology; Neoplasms - mortality; Pancreatic cancer; Prevalence; Risk Factors; Statistical methods; Statistics; Survival; Survival Rate; Young Adult
• ISSN: 0008-543X; 1097-0142; 1097-0142
• DOI: 10.1002/cncr.35458

Background Men exhibit higher prevalence of modifiable risk factors, such as smoking and alcohol consumption, leading to greater cancer incidence and lower survival rates. Comprehensive evidence on global cancer burden among men, including disparities by age group and country, is sparse. To address this, the authors analyzed 30 cancer types among men in 2022, with projections estimated for 2050. Methods The 2022 GLOBOCAN estimates were used to describe cancer statistics for men in 185 countries/territories worldwide. Mortality‐to‐incidence ratios (MIRs) were calculated by dividing age‐standardized mortality rates by incidence rates. Results In 2022, a high MIR (indicating poor survival) was observed among older men (aged 65 years and older; 61%) for rare cancer types (pancreatic cancer, 91%) and in countries with low a Human Development Index (HDI; 74%). Between 2022 and 2050, cancer cases are projected to increase from 10.3 million to 19 million (≥84%). Deaths are projected to increase from 5.4 million to 10.5 million (≥93%), with a greater than two‐fold increase among men aged 65 years and older (≥117%) and for low‐HDI and medium‐HDI countries/territories (≥160%). Cancer cases and deaths are projected to increase among working‐age groups (≥39%) and very‐high‐HDI countries/territories (≥50%). Conclusions Substantial disparities in cancer cases and deaths were observed among men in 2022, and these are projected to widen by 2050. Strengthening health infrastructure, enhancing workforce quality and access, fostering national and international collaborations, and promoting universal health coverage are crucial to reducing cancer disparities and ensuring cancer equity among men globally. In 2022, notable cancer disparities were observed between men’s age groups and between countries/territories, and these disparities are projected to widen by 2050. Strengthening health system infrastructure, improving access to universal health coverage, and multidisciplinary approaches are essential for narrowing existing and projected cancer disparities, ultimately ensuring cancer equity in men worldwide.