Sino-Orbital IgG4 Related Disease- An Uncommon Entity

IgG4 related disease (IgG4-RD) is an auto immune fibro-inflammatory condition, characterised by presence of IgG4 positive lymphoplasmacytic infiltrates and extensive fibrosis of the involved organ. It commonly affects pancreas, biliary tract and salivary glands. Sino-orbital involvement is a relativ...

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Bibliographic Details
Published in:Indian journal of otolaryngology, and head, and neck surgery and head, and neck surgery, 2024-08, Vol.76 (4), p.3661-3665
Main Authors: Sathasivam, Pookamala, Nallasivan, Subramanian, Ramapriyadharshini, C, Jegan, Vishnu
Format: Article
Language:English
Subjects:
Clinical Report
Head and Neck Surgery
Medicine
Medicine & Public Health
Otorhinolaryngology
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Summary:IgG4 related disease (IgG4-RD) is an auto immune fibro-inflammatory condition, characterised by presence of IgG4 positive lymphoplasmacytic infiltrates and extensive fibrosis of the involved organ. It commonly affects pancreas, biliary tract and salivary glands. Sino-orbital involvement is a relatively rare presentation. There is extensive fibrosis of the involved organ. Biopsy is often diagnostic and it shows extensive necrosis and lymphoplasmocytic infiltrates. They show dramatic response to steroid therapy. Here we present three cases of IgG4-RD disease involving orbit and para nasal sinuses who were evaluated and treated in a tertiary care teaching hospital over a period of 2 years.
ISSN:2231-3796
0973-7707
DOI:10.1007/s12070-024-04669-w