Association of proton-density fat fraction with osteoporosis: a systematic review and meta-analysis

Summary This study aimed to evaluate the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, assessing its effectiveness as a biomarker for osteoporosis. A systematic review was conducted by two independent res...

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Bibliographic Details
Published in:Osteoporosis international 2024-12, Vol.35 (12), p.2077-2086
Main Authors: Yuan, Kecheng, Liu, Qingyun, Luo, Penghui, Wang, Changliang, Zhou, Yufu, Qi, Fulang, Zhang, Qing, Huang, Xiaoyan, Qiu, Bensheng
Format: Article
Language:English
Subjects:
Adipose Tissue - diagnostic imaging
Adipose Tissue - pathology
Biomarkers
Biomarkers - analysis
Bone density
Bone Density - physiology
Bone marrow
Bone Marrow - diagnostic imaging
Bone Marrow - pathology
Check lists
Disease management
Endocrinology
Health care
Health risks
Humans
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Medical diagnosis
Medicine
Medicine & Public Health
Meta-analysis
Orthopedics
Osteopenia
Osteoporosis
Osteoporosis - diagnostic imaging
Osteoporosis - physiopathology
Protons
Review
Rheumatology
Risk Factors
Systematic review
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Summary:Summary This study aimed to evaluate the correlation between measuring proton-density fat fraction (PDFF) in bone marrow using multi-echo chemical shift-encoded MRI and osteoporosis, assessing its effectiveness as a biomarker for osteoporosis. A systematic review was conducted by two independent researchers using Cochrane, PubMed, EMBASE, and Web of Science databases up to December 2023. Quality assessments were evaluated using the Cochrane risk of bias tool and the Agency for Healthcare Research and Quality (AHRQ) checklist. Fourteen studies involving 1495 patients were analyzed. The meta-analysis revealed a significant difference in PDFF values between the osteoporosis/osteopenia group and the normal control group, with a mean difference of 11.04 (95% CI: 9.17 to 12.92, Z=11.52, P 
ISSN:0937-941X
1433-2965
1433-2965
DOI:10.1007/s00198-024-07220-3