Changes in Haematological Parameters and Lipid Profiles in Diabetes Mellitus: A Literature Review

• Published in: Curēus (Palo Alto, CA) CA), 2024-07, Vol.16 (7), p.e64201
• Main Authors: Mbah, Jovita I, Bwititi, Phillip T, Gyawali, Prajwal, Nwose, Ezekiel U
• Format: Article
• Language: English
• Subjects: Anemia; Atherosclerosis; Blood platelets; Bone marrow; Cardiovascular disease; Cholesterol; Chronic illnesses; Cytokines; Diabetes; Glucose; Hematology; High density lipoprotein; Hyperglycemia; Inflammation; Insulin resistance; Lipids; Lipoproteins; Metabolic disorders; Mortality; Neutrophils; Oxidative stress; Risk factors; Stem cells
• ISSN: 2168-8184; 2168-8184
• DOI: 10.7759/cureus.64201

Diabetes mellitus is a metabolic disorder characterized by elevated blood glucose that has sequelae on cellular, haematological, and metabolic parameters, including lipid profile disturbed homeostasis, which manifest in alterations in haematological parameters and lipid profiles. These changes in haematological parameters and lipid profiles have been reported by previous research; however, the pattern of these changes and their correlation have not been elucidated. This review aims to assess these changes and investigate the degree of correlation between haematological parameters and lipid profiles in patients with type 2 diabetes mellitus (T2DM). The method adopted was a traditional review approach that included a narrative of concepts and a critical assessment of a few selected articles. Findings highlight that haematological parameters and lipid profiles show varied alterations and correlations in T2DM. For instance, statistical significances at p < 0.05 are reported for WBC count (r = -0.75) showing negative correlations (p < 0.001), where RBC count (r = 0.56) showed correlation with high-density lipoprotein cholesterol (HDLC), whereas anaemia (packed cell volume: r = -0.51) and RBC indices (mean corpuscular volume: r = -0.75; mean corpuscular haemoglobin: r = -089) show negative correlations with total cholesterol (TC). The specific haematological parameters, namely, RBC and WBC with differential and platelet counts, as well as indices, showed varied changes and correlation with lipid profiles, namely, HDLC, low-density lipoprotein cholesterol, TC, and triglyceride, in the six reviewed articles. Diabetes is characterized by changes in haematological parameters and lipid profiles. A better understanding of the negative and positive correlating changes could be utilized in routine evaluation of subjects with prediabetes as well as managing complications in diabetes. Correlation between haematological parameters and lipid profiles over the course of diabetes progression using HbA1c as an index of glucose control is necessary for additional empirical data and updates.