A New Age of Drug Delivery: A Comparative Perspective of Ferritin–Drug Conjugates (FDCs) and Antibody–Drug Conjugates (ADCs)

Ferritin–drug conjugates (FDCs) and antibody–drug conjugates (ADCs) respectively represent the innovative and traditional mainstream approaches in drug delivery systems, each offering unique advantages and challenges. This viewpoint delves into the evolving landscape of drug delivery technologies, s...

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Bibliographic Details
Published in:Bioconjugate chemistry 2024-08, Vol.35 (8), p.1142-1147
Main Authors: Hong, Juanji, Li, Kang, He, Jiuyang, Liang, Minmin
Format: Article
Language:English
Subjects:
Animals
Antibodies
Comparative analysis
Conjugates
Drug delivery
Drug delivery systems
Drug Delivery Systems - methods
Ferritin
Ferritins - chemistry
Humans
Immunoconjugates - chemistry
Impact analysis
Pharmaceutical Preparations - chemistry
Systems analysis
Therapeutic applications
Citations: Items that this one cites
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Summary:Ferritin–drug conjugates (FDCs) and antibody–drug conjugates (ADCs) respectively represent the innovative and traditional mainstream approaches in drug delivery systems, each offering unique advantages and challenges. This viewpoint delves into the evolving landscape of drug delivery technologies, specifically focusing on FDCs and ADCs. Each method exhibits unique advantages and inherent challenges, shaping their roles in therapeutic applications. The article provides a comparative analysis of two delivery systems, FDCs and ADCs, in terms of targeting accuracy, drug loading capacity, and the nature of the payload itself. This comparison offers valuable insights into the distinct advantages and disadvantages associated with each system, enabling a clearer understanding of their potential applications and limitations in therapeutic contexts. This analysis is crucial for optimizing the use of these delivery systems across varying medical contexts, offering a comprehensive overview of their impact on the field of drug delivery.
ISSN:1043-1802
1520-4812
1520-4812
DOI:10.1021/acs.bioconjchem.4c00254