The role of the gut microbiome in modulating immunotherapy efficacy in colorectal cancer

This systematic literature review and meta‐analysis provide an overview of the critical role of gut microbiota in modulating the efficacy of immunotherapy for colorectal cancer. Gut microbes influence host immune responses through multiple mechanisms including modulation of immune cell activity, met...

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Bibliographic Details
Published in:IUBMB life 2024-12, Vol.76 (12), p.1050-1057
Main Authors: Zuo, Siyuan, Huang, Yong, Zou, Junwei
Format: Article
Language:English
Subjects:
colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - immunology
Colorectal Neoplasms - microbiology
Colorectal Neoplasms - pathology
Colorectal Neoplasms - therapy
Dietary supplements
Fecal Microbiota Transplantation
Gastrointestinal Microbiome - immunology
gut microbiota
Humans
Immune checkpoint inhibitors
Immune Checkpoint Inhibitors - pharmacology
Immune Checkpoint Inhibitors - therapeutic use
Immune response
Immunological tolerance
Immunomodulation
Immunotherapy
Immunotherapy - methods
Intestinal microflora
Literature reviews
Meta-analysis
Microbiomes
Microbiota
Microorganisms
Probiotics
Probiotics - therapeutic use
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Summary:This systematic literature review and meta‐analysis provide an overview of the critical role of gut microbiota in modulating the efficacy of immunotherapy for colorectal cancer. Gut microbes influence host immune responses through multiple mechanisms including modulation of immune cell activity, metabolite action, and immune tolerance. The ability of specific gut microbes to improve the efficacy of immune checkpoint inhibitors has been linked to their ability to improve gut barrier function, modulate immune cell activity, and produce key immunomodulatory metabolites such as short‐chain fatty acids. In addition, the composition and diversity of the gut microbiota are strongly associated with the efficacy of immunotherapies, demonstrating the potential to improve therapeutic response by modifying the gut microbiota. This paper also discusses the prospect of manipulating the gut microbiota through strategies such as fecal microbial transplantation, probiotic supplementation, and dietary modifications to optimize the efficacy of immunotherapy.
ISSN:1521-6543
1521-6551
1521-6551
DOI:10.1002/iub.2908