Perinatal Airway Management Mandibular Anomalies: A National Inpatient Cohort Analysis

• Published in: The Laryngoscope 2024-08
• Main Authors: Puricelli, Michael D, Barr, Samantha J, Ellefson, Johanna L, Matabele, Maya N, Nuttall, Elle C, Garcia, Gisselle, Huang, Sabrina X, Venkatesh, Manasa, Lobeck, Inna N
• Format: Article
• Language: English
• ISSN: 1531-4995; 1531-4995
• DOI: 10.1002/lary.31699

To characterize incidence of mandibular anomalies (MAs) and compare gestational age, airway interventions, and complications among individuals with MA phenotypes (isolated retrognathia, isolated micrognathia, syndromic micrognathia, micrognathia plus cleft palate/cleft lip and palate, agnathia/micrognathia plus cervical auricle/otocephaly, and agnathia/micrognathia plus microstomia) and unaffected individuals. The Healthcare Cost and Utilization Project Kids' Inpatient Database was used to collect data over a 20-year period beginning in 2000. Interventions were classified as perinatal when performed on day of life (DOL) 0 or 1 and subsequent when performed during the birth hospitalization after DOL 1. Hypoxic complications included cardiac arrest, birth asphyxia, hypoxic-ischemic encephalopathy, anoxic brain damage, intraventricular hemorrhage or cerebral infarction. Descriptive statistics are reported, and the Rao-Scott chi-square test compared groups. MAs affected 119 per 100,000 birth visits. Preterm delivery was more frequent for all MA phenotypes. Individuals with MA phenotypes are more likely to require medical attention (airway intervention on DOL 0 or 1 OR no airway intervention received but patient sustained hypoxic complication/mortality): 16.2%-70.7% vs. 3.8%, p