Agile 3+ and Agile 4 scores predict chronic kidney disease development in metabolic dysfunction‐associated steatotic liver disease

Summary Background and Aims Despite the development of transient elastography (TE)‐based Agile scores for diagnosing fibrotic burden in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), their applicability in predicting kidney outcomes remains unclear. We aimed to inves...

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Bibliographic Details
Published in:Alimentary pharmacology & therapeutics 2024-10, Vol.60 (8), p.1051-1061
Main Authors: Jung, Chan‐Young, Lee, Jung Il, Ahn, Sang Hoon, Kim, Seung Up, Kim, Beom Seok
Format: Article
Language:English
Subjects:
Epidermal growth factor receptors
Fibrosis
Glomerular filtration rate
Kidney diseases
Liver diseases
Metabolism
Proteinuria
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Summary:Summary Background and Aims Despite the development of transient elastography (TE)‐based Agile scores for diagnosing fibrotic burden in patients with metabolic dysfunction‐associated steatotic liver disease (MASLD), their applicability in predicting kidney outcomes remains unclear. We aimed to investigate the association between liver fibrotic burden, as assessed by Agile scores, and the risk of incident chronic kidney disease (CKD) in patients with MASLD. Methods A total of 3240 participants with MASLD but without pre‐existing CKD who underwent TE between July 2006 and October 2018 were selected. The primary outcome was incident CKD, defined as estimated glomerular filtration rate (eGFR)
ISSN:0269-2813
1365-2036
1365-2036
DOI:10.1111/apt.18213