Genipa americana L.: A Review on Traditional Uses, Phytochemistry and Biological Activities

Genipa americana L. (Rubiaceae), genip tree, has therapeutic and nutritional potential. This revision aimed to gather information on botanical characteristics, popular uses, phytochemical, and pharmacological aspects of the tree. The methodology adopted integrated literature published between 2000 a...

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Bibliographic Details
Published in:Chemistry & biodiversity 2024-11, Vol.21 (11), p.e202400748-n/a
Main Authors: Nascimento, Lariza Leisla Leandro, Oliveira Souza, Geane Gabriele, Silva Mendes, Johnatan Wellisson, Calixto Donelardy, Ana Cecília, Viturino, José Jonas Ferreira, Gomes de Carvalho, Natália Kelly, Leite, Débora Odília Duarte, Costa, José Galberto Martins, Rodrigues, Fabíola Fernandes Galvão
Format: Article
Language:English
Subjects:
Animals
Antioxidants
Antioxidants - chemistry
Antioxidants - pharmacology
Biological activity
Chemical composition
Endemic species
Ethnopharmacology
Genipa Americana
Genipap
Humans
Indigenous species
Insecticides
Intellectual property
Medicine, Traditional
Metabolites
Phytochemicals - chemistry
Phytochemicals - isolation & purification
Phytochemicals - pharmacology
Plant Extracts - chemistry
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Rubiaceae - chemistry
Secondary metabolites
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Summary:Genipa americana L. (Rubiaceae), genip tree, has therapeutic and nutritional potential. This revision aimed to gather information on botanical characteristics, popular uses, phytochemical, and pharmacological aspects of the tree. The methodology adopted integrated literature published between 2000 and 2024, as well as consultations with the World International Intellectual Property Organization (WIPO); resulting in 39 articles and 11 patents to promote this research. The species, which is native and not endemic to Brazil, is most prevalent in the Amazon biome as it is suitable for reconstructing degraded areas, as well as having various traditional applications. Iridoids are the main secondary metabolites present in the species, especially ginipin, geniposide acid, and geniposide, which are the most prevalent in the fruit. The patents registered with the WIPO indicate its use as a colorant, insecticide, anti‐inflammatory, and antioxidant potential, in evidence of its antimicrobial and antioxidant activities. Further studies are needed on the mechanisms of the chemical components’ action and on ethnopharmacology.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202400748