Blood product transfusion practices in neonates with hypoxic-ischemic encephalopathy

Objective Blood product transfusion is a common practice in infants with hypoxic-ischemic encephalopathy (HIE) undoing therapeutic hypothermia (TH). The advantages and disadvantages of conservative or liberal transfusion practices in this fragile population are unknown. Study aims to characterize th...

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Bibliographic Details
Published in:Journal of perinatology 2024-10, Vol.44 (10), p.1485-1490
Main Authors: Miran, Atiyeh A., Stoopler, Michelle, Cizmeci, Mehmet Nevzat, El Shahed, Amr, Yankanah, Rosanna, Danguecan, Ashley, Ly, Linh, Signorile, Marisa, Runeckles, Kyle, Fan, Chun-Po Steve, Kalish, Brian T.
Format: Article
Language:English
Subjects:
692/699/375/2764
692/700/1720
Abnormalities
Blood
Blood Transfusion
Blood transfusions
Brain damage
Death
Encephalopathy
Female
Hematology
Hospital Mortality
Humans
Hypothermia
Hypothermia, Induced
Hypoxia
Hypoxia-Ischemia, Brain - therapy
Impairment
Infant, Newborn
Infants
Intensive Care Units, Neonatal
Ischemia
Male
Medicine
Medicine & Public Health
Mortality
Multivariate Analysis
Neonates
Neurodevelopmental disorders
Newborn babies
Pediatric Surgery
Pediatrics
Plasma
Population studies
Retrospective Studies
Transfusion
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Summary:Objective Blood product transfusion is a common practice in infants with hypoxic-ischemic encephalopathy (HIE) undoing therapeutic hypothermia (TH). The advantages and disadvantages of conservative or liberal transfusion practices in this fragile population are unknown. Study aims to characterize the transfusion practices in infants with HIE and investigate the association with outcome. Study design We conducted a retrospective cohort study at a single level IV NICU, evaluating transfusion thresholds, as well as the association between hematological abnormalities or blood product transfusions and outcomes in infants admitted with HIE. Result By univariate analysis, FFP transfusion was associated with increased in-hospital death. However, multivariate analysis adjusting for HIE severity demonstrated no association between hematological abnormality or blood product transfusion and death, nor with neurodevelopmental impairment. Conclusion No association was found between hematological blood product transfusion and death or neurodevelopmental impairment in a retrospective single NICU study of infants with HIE.
ISSN:0743-8346
1476-5543
1476-5543
DOI:10.1038/s41372-024-02092-1