Characterization of the vaginal microbiota in Italian women with endometriosis: preliminary study

Purpose This cross-sectional study aims to assess the interplay between the vaginal microbiota and endometriosis. Methods 123 consecutive Italian fertile women, aged between 20 and 40 years old, were enrolled during a routine gynecological consultation; 24 were diagnosed with endometriosis and 99 di...

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Published in:Archives of gynecology and obstetrics 2024-10, Vol.310 (4), p.2141-2151
Main Authors: Sessa, Rosa, Filardo, Simone, Viscardi, Maria Federica, Brandolino, Gabriella, Muzii, Ludovico, Di Pietro, Marisa, Porpora, Maria Grazia
Format: Article
Language:English
Subjects:
Adult
Bacteria - classification
Bacteria - genetics
Bacteria - isolation & purification
Cross-Sectional Studies
Dysbiosis - microbiology
Endocrinology
Endometriosis
Endometriosis - microbiology
Female
General Gynecology
Gynecological diseases
Gynecology
Human Genetics
Humans
Italy
Medicine
Medicine & Public Health
Microbiota
Obstetrics/Perinatology/Midwifery
RNA, Ribosomal, 16S - genetics
Vagina
Vagina - microbiology
Young Adult
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Summary:Purpose This cross-sectional study aims to assess the interplay between the vaginal microbiota and endometriosis. Methods 123 consecutive Italian fertile women, aged between 20 and 40 years old, were enrolled during a routine gynecological consultation; 24 were diagnosed with endometriosis and 99 did not complain of any gynecological disease. All women underwent a vaginal swab for the evaluation of the composition and diversity of vaginal microbiota by means of 16 s rDNA metagenomic sequencing. Results Compared to women with no gynecological disease, the vaginal microbiota in women with endometriosis showed a similar abundance of Lactobacillus spp.; however, a statistically significant lower abundance in the genera Pseudomonas ( p  
ISSN:1432-0711
0932-0067
1432-0711
DOI:10.1007/s00404-024-07631-x