Vitamin D status in pregnancy and cord blood is associated with symptoms of attention-deficit hyperactivity disorder at age 5 years: Results from Odense Child Cohort

Background: Vitamin D status in pregnancy may affect offspring neurodevelopment. Objective: The objective was to investigate the association between serum 25-hydroxyvitamin D in cord blood and pregnancy and symptoms of attention-deficit hyperactivity disorder in 5-year-old offspring. Method: In Oden...

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Bibliographic Details
Published in:Australian and New Zealand journal of psychiatry 2024-12, Vol.58 (12), p.1090-1102
Main Authors: Thinggaard, Camilla Munk, Dalgård, Christine, Möller, Sören, Christesen, Henrik Boye Thybo, Bilenberg, Niels
Format: Article
Language:English
Subjects:
Adult
Attention Deficit Disorder with Hyperactivity - blood
Attention Deficit Disorder with Hyperactivity - epidemiology
Child, Preschool
Cohort Studies
Denmark - epidemiology
Female
Fetal Blood
Humans
Infant
Male
Pregnancy
Pregnancy Complications - blood
Pregnancy Complications - epidemiology
Prenatal Exposure Delayed Effects - blood
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamin D Deficiency - blood
Vitamin D Deficiency - complications
Vitamin D Deficiency - epidemiology
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Summary:Background: Vitamin D status in pregnancy may affect offspring neurodevelopment. Objective: The objective was to investigate the association between serum 25-hydroxyvitamin D in cord blood and pregnancy and symptoms of attention-deficit hyperactivity disorder in 5-year-old offspring. Method: In Odense Child Cohort, Denmark, 944 mother–child pairs had data on pregnancy or cord serum 25-hydroxyvitamin D and parent-rated attention-deficit hyperactivity disorder symptom score by Child Behavior Checklist for ages 1.5–5 years. Adjusted multiple linear regression and two-stage exposure analyses were performed for serum 25-hydroxyvitamin D associations to the attention-deficit hyperactivity disorder symptom score. Results: The mean (standard deviation) serum 25-hydroxyvitamin D in cord blood was 48.0 (21.8) nmol/L; early pregnancy was 65.5 (20.2) nmol/L and late pregnancy was 79.3 (25.7) nmol/L. The median (interquartile range) age of child at examination was 5.2 (5.1–5.4) years and median (interquartile range) attention-deficit hyperactivity disorder symptom score was 2 (0–3) points. In adjusted analyses, serum 25-hydroxyvitamin D of
ISSN:0004-8674
1440-1614
1440-1614
DOI:10.1177/00048674241272018