Efficacy of ozone therapy for oral mucosa wound healing: a systematic review and meta-analysis

Objectives To conduct a systematic review and meta-analysis to assess the effectiveness of ozone therapy in oral ulcers healing when compared to placebo or active treatments. Materials and methods The search was carried out using PubMed, EMBASE, Scopus, and Lilacs databases. Clinical trials involvin...

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Published in:Clinical oral investigations 2024-08, Vol.28 (9), p.490, Article 490
Main Authors: Maglia, Deisi Romitti, Souza, Bruna do Amaral Ferreira, Visioli, Fernanda
Format: Article
Language:English
Subjects:
Clinical trials
Dentistry
Humans
Medicine
Meta-analysis
Mouth Mucosa - drug effects
Oral Ulcer - drug therapy
Oral Ulcer - therapy
Ozone
Ozone - therapeutic use
Pain
Pain management
Placebo effect
Placebos
Quality of life
Review
Steroids
Systematic review
Ulcers
Wound healing
Wound Healing - drug effects
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Summary:Objectives To conduct a systematic review and meta-analysis to assess the effectiveness of ozone therapy in oral ulcers healing when compared to placebo or active treatments. Materials and methods The search was carried out using PubMed, EMBASE, Scopus, and Lilacs databases. Clinical trials involving human participants were included. The Risk Ratio (RR) and the standardized mean difference (SMD) with 95%CI (confidence interval) were calculated. The ROBINS-I (risk of bias in non-randomized studies of interventions) and RoB2 (risk of bias tool for randomized trials) assessment tool was used to detect bias. Results After the selection process, 12 studies were included. The meta-analysis showed that ozone therapy helps to reduce the size of the traumatic and autoimmune ulcers (RR=-0.44; 95% CI -0.71,-0.17; I 2 =0%) in comparison to placebo. Regarding pain reduction, ozone was superior to placebo (RR = 1.29, 95% CI -1.6 to -0.95); I 2 =0%), and equivalent to topical corticosteroid and laser photobiomodulation (RR = 0.26, 95% CI -0.27,0.78, p  = 0.34). Conclusion Ozone therapy is an alternative for accelerating healing and reducing pain for both traumatic and autoimmune ulcers. However, the quality of evidence is limited. Clinical relevance Oral ulcerations are usually painful and impact quality of life requiring different approaches to boost wound healing and reduce symptoms. For this purpose, ozone therapy is a promising strategy.
ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-024-05873-2