Adipose-derived stem cell conditioned medium for hair regeneration therapy in alopecia: a review of literature

To date, therapeutic choices for alopecia have shown limited effectiveness and safety, making the discovery of new therapeutic choices challenging. Adipose-derived stem cells conditioned-medium (ADSC-CM) contain various growth factors released by ADSCs that may support hair regrowth. This literature...

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Bibliographic Details
Published in:Archives of dermatological research 2024-08, Vol.316 (8), p.525, Article 525
Main Authors: Legiawati, Lili, Suseno, Lis Surachmiati, Sitohang, Irma Bernadette S., Yusharyahya, Shannaz Nadia, Fahira, Alessa, Ramadan, Edwin Ti, Paramastri, Kanya
Format: Article
Language:English
Subjects:
Adipose Tissue - cytology
Alopecia
Alopecia - therapy
Baldness
Culture Media, Conditioned
Dermatology
Growth factors
Hair - drug effects
Hair - growth & development
Hair Follicle
Humans
Literature reviews
Medicine
Medicine & Public Health
Regeneration - drug effects
Review
Stem cells
Treatment Outcome
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Summary:To date, therapeutic choices for alopecia have shown limited effectiveness and safety, making the discovery of new therapeutic choices challenging. Adipose-derived stem cells conditioned-medium (ADSC-CM) contain various growth factors released by ADSCs that may support hair regrowth. This literature review aims to discover the effect and clinical impact of ADSC-CM in the treatment of alopecia. A comprehensive literature search was performed through four databases (Pubmed, ScienceDirect, Cochrane, and Scopus) in September 2021. A combination of search terms including “adipose-derived stem cells” and “alopecia” was used. Studies published in English that included ADSC-CM interventions on alopecia of all types were selected and summarized. A total of five studies were selected for review, all of which were case series. All studies showed a positive outcome for intervention. Outcomes measured in the studies include hair count or hair density, hair thickness, anagen, and telogen hair count. No adverse effects were reported from all studies. Limitations lie in the differences in intervention method, application, and length of treatment. ADSC-CM hair regeneration therapy is an effective and safe treatment for alopecia that may be combined with other types of therapy to improve outcomes.
ISSN:1432-069X
0340-3696
1432-069X
DOI:10.1007/s00403-024-03255-y