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Pre-transplant Anemia as a Marker of Short-term Outcomes in Lung Transplant Recipients

Anemia is a risk factor for increased morbidity and mortality in multiple medical conditions, yet the impact of pretransplant anemia in patients with advanced lung disease on post-transplant outcomes remains under-explored. We sought to determine whether pretransplant anemia serves as a marker of al...

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Bibliographic Details
Published in:Transplantation proceedings 2024-09, Vol.56 (7), p.1654-1658
Main Authors: Trindade, Anil J., Fortier, Avery K., Tucker, William D., Martel, Abigail K., Gannon, Whitney D., Bacchetta, Matthew
Format: Article
Language:English
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Summary:Anemia is a risk factor for increased morbidity and mortality in multiple medical conditions, yet the impact of pretransplant anemia in patients with advanced lung disease on post-transplant outcomes remains under-explored. We sought to determine whether pretransplant anemia serves as a marker of altered inflammation in the host and associates with short-term outcomes following lung transplantation. We performed a single-center, retrospective analysis of 238 lung transplant recipients. We assessed for risk factors of pretransplant anemia and identified associations with short-term post-transplant outcomes. Pretransplant anemia was associated with increased intraoperative transfusion of packed red blood cells and a trend towards increased index hospital length of stay and 1-year mortality. Conversely, pretransplant anemia was associated with a decreased incidence of acute cellular rejection. These preliminary data suggest that anemia may be a biomarker of altered inflammation in the host recipient and influences post-transplant outcomes.
ISSN:0041-1345
1873-2623
1873-2623
DOI:10.1016/j.transproceed.2024.06.007