Transcriptional signatures of cortical structural changes in chronic insomnia disorder

Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclea...

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Bibliographic Details
Published in:Psychophysiology 2024-12, Vol.61 (12), p.e14671-n/a
Main Authors: Yu, Liyong, Hu, Daijie, Luo, Yucai, Lin, Wenting, Xu, Hao, Xiao, Xiangwen, Xia, Zihao, Dou, Zeyang, Zhao, Guangli, Yang, Lu, Peng, Dezhong, Zhang, Qi, Yu, Siyi
Format: Article
Language:English
Subjects:
Adult
Brain architecture
Cerebral Cortex - diagnostic imaging
Cerebral Cortex - pathology
chronic Insomnia disorder
Female
Gene expression
Humans
Insomnia
Magnetic Resonance Imaging
Male
Middle Aged
Molecular modelling
morphometric similarity
Neuroimaging
Physical characteristics
sleep < content/topics
Sleep disorders
Sleep Initiation and Maintenance Disorders - diagnostic imaging
Sleep Initiation and Maintenance Disorders - genetics
Sleep Initiation and Maintenance Disorders - pathology
Transcriptome
Transcriptomes
Transcriptomics
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Summary:Chronic insomnia disorder (CID) is a multidimensional disease that may influence various levels of brain organization, spanning the macroscopic structural connectome to microscopic gene expression. However, the connection between genomic variations and morphological alterations in CID remains unclear. Here, we investigated brain structural changes in CID patients at the whole‐brain level and whether these link to transcriptional characteristics. Brain structural data from 104 CID patients and 102 matched healthy controls (HC) were acquired to examine cortical structural alterations using morphometric similarity (MS) analysis. Partial least squares (PLS) regression and transcriptome data from the Allen Human Brain Atlas were used to extract genomes related to MS changes. Gene‐category enrichment analysis (GCEA) was used to identify potential molecular mechanisms behind the observed structural changes. We found that CID patients exhibited MS reductions in the parietal and limbic regions, along with enhancements in the temporal and frontal regions compared to HCs (pFDR 
ISSN:0048-5772
1469-8986
1469-8986
1540-5958
DOI:10.1111/psyp.14671