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High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP
•Heart failure may limit the blood stream to achieve clinical recovery.•Whether BNP level was related to the outcome after thrombectomy was studied.•In AF patients, favorable outcome was in 76% vs. 47%, as BNP
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| Published in: | Journal of stroke and cerebrovascular diseases 2024-11, Vol.33 (11), p.107943, Article 107943 |
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| container_title | Journal of stroke and cerebrovascular diseases |
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| creator | Aoki, Junya Suzuki, Kentaro Sakamoto, Yuki Matsumaru, Yuji Takeuchi, Masataka Morimoto, Masafumi Kanazawa, Ryuzaburo Takayama, Yohei Kamiya, Yuki Shigeta, Keigo Okubo, Seiji Hayakawa, Mikito Ishii, Norihiro Koguchi, Yorio Takigawa, Tomoji Inoue, Masato Naito, Hiromichi Ota, Takahiro Hirano, Teruyuki Kato, Noriyuki Ueda, Toshihiro Iguchi, Yasuyuki Akaji, Kazunori Tsuruta, Wataro Miki, Kazunori Fujimoto, Shigeru Higashida, Tetsuhiro Iwasaki, Mitsuhiro Kanamaru, Takuya Saito, Tomonari Katano, Takehiro Kutsuna, Akihito Nishiyama, Yasuhiro Otsuka, Toshiaki Kimura, Kazumi |
| description | •Heart failure may limit the blood stream to achieve clinical recovery.•Whether BNP level was related to the outcome after thrombectomy was studied.•In AF patients, favorable outcome was in 76% vs. 47%, as BNP |
| doi_str_mv | 10.1016/j.jstrokecerebrovasdis.2024.107943 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3094821053</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S1052305724003872</els_id><sourcerecordid>3094821053</sourcerecordid><originalsourceid>FETCH-LOGICAL-c269t-c1458e8217d563bec7c0bc0829c1074ce80c018720f874f1f75109be156c26343</originalsourceid><addsrcrecordid>eNqVkcFu1DAQhi1ERUvLKyAfEVIWO443SW901dKKFazU9mw5kwnxksSLx9tq3x5XaTlx6ckj-dM3mv9n7LMUCynk8st2saUY_G8EDNgE_2CpdbTIRV4koKwL9YadSK3yrNJSvk2z0HmmhC6P2XuirRBS6kq_Y8eqlrquhTxhj9fuV893g6XR8osfGw5-ApxisNH5iVsiD85GJP7oYs9hcJMDO3C_j-BH5LaLGPiI0Nv5I_bBjw1C9OPhnG88Rd574Hayw4Eccd_x2-83mzN21NmB8MPze8rury7vVtfZ-ue3m9XXdQb5so4ZyEJXWOWybPVSJW0JogFR5TWkiwvASoCQVZmLriqLTnallqJuUOplEqhCnbJPs3cX_J89UjSjI8BhsBP6PRkl6iLphVYJvZhRCJ4oYGd2wY02HIwU5qkAszX_K8A8FWDmApLk4_O-fTNi-0_xkngC1jOA6eoHh8EQOEyZty6k1Ezr3Wv2_QVoA6Y6</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3094821053</pqid></control><display><type>article</type><title>High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP</title><source>ScienceDirect Freedom Collection 2022-2024</source><creator>Aoki, Junya ; Suzuki, Kentaro ; Sakamoto, Yuki ; Matsumaru, Yuji ; Takeuchi, Masataka ; Morimoto, Masafumi ; Kanazawa, Ryuzaburo ; Takayama, Yohei ; Kamiya, Yuki ; Shigeta, Keigo ; Okubo, Seiji ; Hayakawa, Mikito ; Ishii, Norihiro ; Koguchi, Yorio ; Takigawa, Tomoji ; Inoue, Masato ; Naito, Hiromichi ; Ota, Takahiro ; Hirano, Teruyuki ; Kato, Noriyuki ; Ueda, Toshihiro ; Iguchi, Yasuyuki ; Akaji, Kazunori ; Tsuruta, Wataro ; Miki, Kazunori ; Fujimoto, Shigeru ; Higashida, Tetsuhiro ; Iwasaki, Mitsuhiro ; Kanamaru, Takuya ; Saito, Tomonari ; Katano, Takehiro ; Kutsuna, Akihito ; Nishiyama, Yasuhiro ; Otsuka, Toshiaki ; Kimura, Kazumi</creator><creatorcontrib>Aoki, Junya ; Suzuki, Kentaro ; Sakamoto, Yuki ; Matsumaru, Yuji ; Takeuchi, Masataka ; Morimoto, Masafumi ; Kanazawa, Ryuzaburo ; Takayama, Yohei ; Kamiya, Yuki ; Shigeta, Keigo ; Okubo, Seiji ; Hayakawa, Mikito ; Ishii, Norihiro ; Koguchi, Yorio ; Takigawa, Tomoji ; Inoue, Masato ; Naito, Hiromichi ; Ota, Takahiro ; Hirano, Teruyuki ; Kato, Noriyuki ; Ueda, Toshihiro ; Iguchi, Yasuyuki ; Akaji, Kazunori ; Tsuruta, Wataro ; Miki, Kazunori ; Fujimoto, Shigeru ; Higashida, Tetsuhiro ; Iwasaki, Mitsuhiro ; Kanamaru, Takuya ; Saito, Tomonari ; Katano, Takehiro ; Kutsuna, Akihito ; Nishiyama, Yasuhiro ; Otsuka, Toshiaki ; Kimura, Kazumi ; SKIP study Investigators</creatorcontrib><description>•Heart failure may limit the blood stream to achieve clinical recovery.•Whether BNP level was related to the outcome after thrombectomy was studied.•In AF patients, favorable outcome was in 76% vs. 47%, as BNP <186 vs. ≥186 pg/mL.•Without AF, favorable outcomes was in 68% vs. 33% for BNP <186 vs. ≥186 pg/mL.•High plasma BNP concentration was associated with unfavorable outcome after MT.
Heart failure may result in reduced brain perfusion, limiting the blood flow needed to achieve clinical recovery. We investigated whether plasma levels of brain natriuretic peptide (BNP), a biological marker of heart failure, were related to clinical outcomes after mechanical thrombectomy (MT).
Data were analyzed from stroke patients with internal carotid or middle cerebral artery occlusion enrolled in the SKIP trial for whom plasma level of BNP was evaluated on admission. Favorable outcome was defined as a modified Rankin scale score of 0–2 at 3 months.
Among 169 patients (median age, 74 years; 62% men, median National Institutes of Health Stroke Scale score, 18), 104 (62%) achieved favorable outcomes. Median plasma BNP level was lower in the favorable outcome group (124.1 pg/mL; interquartile range [IQR], 62.1–215.5 pg/mL) than in the unfavorable outcome group (198.0 pg/mL; IQR, 74.8–334.0 pg/mL; p=0.005). In multivariate regression analysis, the adjusted odds ratio for BNP for favorable outcomes was 0.971 (95% confidence interval, 0.993–0.999; p=0.048). At 3 months after onset, the favorable outcome rate was lower in the ≥186 pg/mL group (45%) than in the <186 pg/mL group (72%; p=0.001). This significant difference remained regardless of the presence of atrial fibrillation (AF), with rates of 47% and 76%, respectively, in AF patients (p=0.003) and 33% and 68%, respectively, in patients without AF (p=0.046).
High plasma BNP concentration appears associated with unfavorable outcomes after MT.</description><identifier>ISSN: 1052-3057</identifier><identifier>ISSN: 1532-8511</identifier><identifier>EISSN: 1532-8511</identifier><identifier>DOI: 10.1016/j.jstrokecerebrovasdis.2024.107943</identifier><identifier>PMID: 39159901</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Acute stroke ; Atrial fibrillation ; Brain natriuretic peptide ; Endovascular recanalization ; Heart failure</subject><ispartof>Journal of stroke and cerebrovascular diseases, 2024-11, Vol.33 (11), p.107943, Article 107943</ispartof><rights>2024</rights><rights>Copyright © 2024. Published by Elsevier Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c269t-c1458e8217d563bec7c0bc0829c1074ce80c018720f874f1f75109be156c26343</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,778,782,27911,27912</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39159901$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Aoki, Junya</creatorcontrib><creatorcontrib>Suzuki, Kentaro</creatorcontrib><creatorcontrib>Sakamoto, Yuki</creatorcontrib><creatorcontrib>Matsumaru, Yuji</creatorcontrib><creatorcontrib>Takeuchi, Masataka</creatorcontrib><creatorcontrib>Morimoto, Masafumi</creatorcontrib><creatorcontrib>Kanazawa, Ryuzaburo</creatorcontrib><creatorcontrib>Takayama, Yohei</creatorcontrib><creatorcontrib>Kamiya, Yuki</creatorcontrib><creatorcontrib>Shigeta, Keigo</creatorcontrib><creatorcontrib>Okubo, Seiji</creatorcontrib><creatorcontrib>Hayakawa, Mikito</creatorcontrib><creatorcontrib>Ishii, Norihiro</creatorcontrib><creatorcontrib>Koguchi, Yorio</creatorcontrib><creatorcontrib>Takigawa, Tomoji</creatorcontrib><creatorcontrib>Inoue, Masato</creatorcontrib><creatorcontrib>Naito, Hiromichi</creatorcontrib><creatorcontrib>Ota, Takahiro</creatorcontrib><creatorcontrib>Hirano, Teruyuki</creatorcontrib><creatorcontrib>Kato, Noriyuki</creatorcontrib><creatorcontrib>Ueda, Toshihiro</creatorcontrib><creatorcontrib>Iguchi, Yasuyuki</creatorcontrib><creatorcontrib>Akaji, Kazunori</creatorcontrib><creatorcontrib>Tsuruta, Wataro</creatorcontrib><creatorcontrib>Miki, Kazunori</creatorcontrib><creatorcontrib>Fujimoto, Shigeru</creatorcontrib><creatorcontrib>Higashida, Tetsuhiro</creatorcontrib><creatorcontrib>Iwasaki, Mitsuhiro</creatorcontrib><creatorcontrib>Kanamaru, Takuya</creatorcontrib><creatorcontrib>Saito, Tomonari</creatorcontrib><creatorcontrib>Katano, Takehiro</creatorcontrib><creatorcontrib>Kutsuna, Akihito</creatorcontrib><creatorcontrib>Nishiyama, Yasuhiro</creatorcontrib><creatorcontrib>Otsuka, Toshiaki</creatorcontrib><creatorcontrib>Kimura, Kazumi</creatorcontrib><creatorcontrib>SKIP study Investigators</creatorcontrib><title>High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP</title><title>Journal of stroke and cerebrovascular diseases</title><addtitle>J Stroke Cerebrovasc Dis</addtitle><description>•Heart failure may limit the blood stream to achieve clinical recovery.•Whether BNP level was related to the outcome after thrombectomy was studied.•In AF patients, favorable outcome was in 76% vs. 47%, as BNP <186 vs. ≥186 pg/mL.•Without AF, favorable outcomes was in 68% vs. 33% for BNP <186 vs. ≥186 pg/mL.•High plasma BNP concentration was associated with unfavorable outcome after MT.
Heart failure may result in reduced brain perfusion, limiting the blood flow needed to achieve clinical recovery. We investigated whether plasma levels of brain natriuretic peptide (BNP), a biological marker of heart failure, were related to clinical outcomes after mechanical thrombectomy (MT).
Data were analyzed from stroke patients with internal carotid or middle cerebral artery occlusion enrolled in the SKIP trial for whom plasma level of BNP was evaluated on admission. Favorable outcome was defined as a modified Rankin scale score of 0–2 at 3 months.
Among 169 patients (median age, 74 years; 62% men, median National Institutes of Health Stroke Scale score, 18), 104 (62%) achieved favorable outcomes. Median plasma BNP level was lower in the favorable outcome group (124.1 pg/mL; interquartile range [IQR], 62.1–215.5 pg/mL) than in the unfavorable outcome group (198.0 pg/mL; IQR, 74.8–334.0 pg/mL; p=0.005). In multivariate regression analysis, the adjusted odds ratio for BNP for favorable outcomes was 0.971 (95% confidence interval, 0.993–0.999; p=0.048). At 3 months after onset, the favorable outcome rate was lower in the ≥186 pg/mL group (45%) than in the <186 pg/mL group (72%; p=0.001). This significant difference remained regardless of the presence of atrial fibrillation (AF), with rates of 47% and 76%, respectively, in AF patients (p=0.003) and 33% and 68%, respectively, in patients without AF (p=0.046).
High plasma BNP concentration appears associated with unfavorable outcomes after MT.</description><subject>Acute stroke</subject><subject>Atrial fibrillation</subject><subject>Brain natriuretic peptide</subject><subject>Endovascular recanalization</subject><subject>Heart 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Inc</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20241101</creationdate><title>High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP</title><author>Aoki, Junya ; Suzuki, Kentaro ; Sakamoto, Yuki ; Matsumaru, Yuji ; Takeuchi, Masataka ; Morimoto, Masafumi ; Kanazawa, Ryuzaburo ; Takayama, Yohei ; Kamiya, Yuki ; Shigeta, Keigo ; Okubo, Seiji ; Hayakawa, Mikito ; Ishii, Norihiro ; Koguchi, Yorio ; Takigawa, Tomoji ; Inoue, Masato ; Naito, Hiromichi ; Ota, Takahiro ; Hirano, Teruyuki ; Kato, Noriyuki ; Ueda, Toshihiro ; Iguchi, Yasuyuki ; Akaji, Kazunori ; Tsuruta, Wataro ; Miki, Kazunori ; Fujimoto, Shigeru ; Higashida, Tetsuhiro ; Iwasaki, Mitsuhiro ; Kanamaru, Takuya ; Saito, Tomonari ; Katano, Takehiro ; Kutsuna, Akihito ; Nishiyama, Yasuhiro ; Otsuka, Toshiaki ; Kimura, 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Masato</au><au>Naito, Hiromichi</au><au>Ota, Takahiro</au><au>Hirano, Teruyuki</au><au>Kato, Noriyuki</au><au>Ueda, Toshihiro</au><au>Iguchi, Yasuyuki</au><au>Akaji, Kazunori</au><au>Tsuruta, Wataro</au><au>Miki, Kazunori</au><au>Fujimoto, Shigeru</au><au>Higashida, Tetsuhiro</au><au>Iwasaki, Mitsuhiro</au><au>Kanamaru, Takuya</au><au>Saito, Tomonari</au><au>Katano, Takehiro</au><au>Kutsuna, Akihito</au><au>Nishiyama, Yasuhiro</au><au>Otsuka, Toshiaki</au><au>Kimura, Kazumi</au><aucorp>SKIP study Investigators</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP</atitle><jtitle>Journal of stroke and cerebrovascular diseases</jtitle><addtitle>J Stroke Cerebrovasc Dis</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>33</volume><issue>11</issue><spage>107943</spage><pages>107943-</pages><artnum>107943</artnum><issn>1052-3057</issn><issn>1532-8511</issn><eissn>1532-8511</eissn><abstract>•Heart failure may limit the blood stream to achieve clinical recovery.•Whether BNP level was related to the outcome after thrombectomy was studied.•In AF patients, favorable outcome was in 76% vs. 47%, as BNP <186 vs. ≥186 pg/mL.•Without AF, favorable outcomes was in 68% vs. 33% for BNP <186 vs. ≥186 pg/mL.•High plasma BNP concentration was associated with unfavorable outcome after MT.
Heart failure may result in reduced brain perfusion, limiting the blood flow needed to achieve clinical recovery. We investigated whether plasma levels of brain natriuretic peptide (BNP), a biological marker of heart failure, were related to clinical outcomes after mechanical thrombectomy (MT).
Data were analyzed from stroke patients with internal carotid or middle cerebral artery occlusion enrolled in the SKIP trial for whom plasma level of BNP was evaluated on admission. Favorable outcome was defined as a modified Rankin scale score of 0–2 at 3 months.
Among 169 patients (median age, 74 years; 62% men, median National Institutes of Health Stroke Scale score, 18), 104 (62%) achieved favorable outcomes. Median plasma BNP level was lower in the favorable outcome group (124.1 pg/mL; interquartile range [IQR], 62.1–215.5 pg/mL) than in the unfavorable outcome group (198.0 pg/mL; IQR, 74.8–334.0 pg/mL; p=0.005). In multivariate regression analysis, the adjusted odds ratio for BNP for favorable outcomes was 0.971 (95% confidence interval, 0.993–0.999; p=0.048). At 3 months after onset, the favorable outcome rate was lower in the ≥186 pg/mL group (45%) than in the <186 pg/mL group (72%; p=0.001). This significant difference remained regardless of the presence of atrial fibrillation (AF), with rates of 47% and 76%, respectively, in AF patients (p=0.003) and 33% and 68%, respectively, in patients without AF (p=0.046).
High plasma BNP concentration appears associated with unfavorable outcomes after MT.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>39159901</pmid><doi>10.1016/j.jstrokecerebrovasdis.2024.107943</doi></addata></record> |
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| source | ScienceDirect Freedom Collection 2022-2024 |
| subjects | Acute stroke Atrial fibrillation Brain natriuretic peptide Endovascular recanalization Heart failure |
| title | High plasma BNP concentration associates with clinical outcome after mechanical thrombectomy: Post hoc analysis of SKIP |
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