Magnesium, selenium and zinc deficiency compromises antioxidant defense in women with obesity

• Published in: Biometals 2024-12, Vol.37 (6), p.1551-1563
• Main Authors: de Oliveira, Ana Raquel Soares, Cruz, Kyria Jayanne Clímaco, Morais, Jennifer Beatriz Silva, dos Santos, Loanne Rocha, de Sousa Melo, Stéfany Rodrigues, Fontenelle, Larissa Cristina, Severo, Juliana Soares, Beserra, Jéssica Batista, de Sousa, Thayanne Gabryelle Visgueira, de Freitas, Suelem Torres, de Oliveira, Emyle Horrana Serafim, Maia, Carla Soraya Costa, de Matos Neto, Emídio Marques, de Oliveira, Francisco Erasmo, Henriques, Gilberto Simeone, Marreiro, Dilina do Nascimento
• Format: Article
• Language: English
• Subjects: Adult; Antioxidants; Antioxidants - metabolism; Beta cells; Biochemistry; Biomedical and Life Sciences; Catalase; Cell Biology; Diet; Dietary intake; Dietary minerals; Erythrocytes; Erythrocytes - metabolism; Eutrophication; Fasting; Female; Food intake; Glutathione; Glutathione peroxidase; Glutathione Peroxidase - blood; Glutathione Peroxidase - metabolism; Hemoglobin; Homeostasis; Humans; Insulin; Insulin resistance; Leptin; Life Sciences; Lipids; Magnesium; Magnesium - blood; Magnesium - urine; Magnesium Deficiency - blood; Medicine/Public Health; Metabolic disorders; Microbiology; Middle Aged; Minerals; Nutrient deficiency; Obesity; Obesity - blood; Obesity - metabolism; Oxidative stress; Peroxidase; Pharmacology/Toxicology; Plant Physiology; Plasma; Selenium; Selenium - blood; Selenium - deficiency; Selenium - urine; Serum lipids; Superoxide dismutase; Superoxide Dismutase - blood; Thiobarbituric acid; Zinc; Zinc - blood; Zinc - deficiency
• ISSN: 0966-0844; 1572-8773; 1572-8773
• DOI: 10.1007/s10534-024-00625-x

Studies have shown that deficiencies in magnesium, selenium, and zinc in individuals with obesity compromise the endogenous antioxidant defense system. This study aimed to evaluate the impact of mineral deficiency on enzymatic antioxidant defense in women with obesity. The study involved 63 women with obesity (BMI ≥ 35 kg/m 2 ) and 77 eutrophic women (BMI between 18.5 and 24.9 kg/m 2 ). Variables such as fasting glucose, glycated hemoglobin, fasting insulin, and serum lipids were analyzed. Insulin resistance was measured using the homeostasis assessment model (HOMA-IR) and beta cell function using the homeostasis assessment model (HOMA-β). Dietary intake of energy, macronutrients (including magnesium, zinc, and selenium), and plasma, erythrocyte, and urinary concentrations of these minerals were measured and analyzed. Serum cortisol, plasma leptin, plasma thiobarbituric acid reactive substances, and the activity of erythrocyte superoxide dismutase (SOD), erythrocyte glutathione peroxidase (GPX), and erythrocyte catalase were also analyzed. Women with obesity had reduced plasma and erythrocyte concentrations and greater urinary excretion of all minerals compared to normal weight women (p