Molecular imaging with 68Ga-PSMA PET/CT in high grade glioma: A biomarker for tumour neo-angiogenesis

There are several promising radiotracers used for both staging and restaging of primary and recurrent brain tumours based on various mechanisms of tracer localization in tumour cells. 68Ga-PSMA PET has extremely low background uptake in normal brain tissue and consequently high tumour-to-brain ratio...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Pakistan Medical Association 2024-08, Vol.74 (8), p.1552-1554
Main Authors: Usmani, Sharjeel, Riyami, Khulood Al, Numani, Shah P, Hashmi, Syed Furqan, Jain, Anjali, Sukaiti, Rashid Al, Ahmed, Najeeb, Shamim, Muhammad Shahzad
Format: Article
Language:English
Subjects:
Angiogenesis
Biomarkers, Tumor - metabolism
Brain Neoplasms - diagnostic imaging
Brain Neoplasms - pathology
Edetic Acid - analogs & derivatives
Gallium Isotopes
Gallium Radioisotopes
Glioma - diagnostic imaging
Glioma - pathology
Gliomas
Health aspects
Humans
Methods
Molecular Imaging - methods
Neoplasm Grading
Neovascularization
Neovascularization, Pathologic - diagnostic imaging
Oligopeptides
PET imaging
Physiological aspects
Positron Emission Tomography Computed Tomography - methods
Radiopharmaceuticals
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:There are several promising radiotracers used for both staging and restaging of primary and recurrent brain tumours based on various mechanisms of tracer localization in tumour cells. 68Ga-PSMA PET has extremely low background uptake in normal brain tissue and consequently high tumour-to-brain ratio making it a promising imaging radiotracer for gliomas. 68Ga-PSMA demonstrates utility in evaluating high grade glioma during both initial workup or when suspecting recurrence. Herein the authors evaluate the role of this imaging modality and the potential future it holds in the management of high grade gliomas.
ISSN:0030-9982
0030-9982
DOI:10.47391/JPMA.24-64