Visual deterioration outcomes following optic pathway glioma treatment: a 12-year single institution retrospective study

Objective The surgical treatment of optic pathway gliomas (OPG) remains controversial, with visual outcomes often unpredictable. The present study explored surgical and clinical factors influencing visual acuity (VA) after OPG treatment and developed anatomical subtypes correlated with clinical symp...

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Bibliographic Details
Published in:Journal of neuro-oncology 2024-11, Vol.170 (2), p.363-375
Main Authors: Zhou, Wen-Tao, Niu, Jia-Hao, Liao, Chihyi, Ren, Si-Kang, Ou, Yun-wei, Liu, Wei, Li, Chun-De, Gong, Jian, Tian, Yong-Ji
Format: Article
Language:English
Subjects:
Acuity
Adolescent
Child
Child, Preschool
Classification
Correlation analysis
Decision trees
Female
Follow-Up Studies
Glioma
Humans
Male
Medicine
Medicine & Public Health
Neurology
Oncology
Optic Nerve Glioma - surgery
Osteoprotegerin
Patients
Postoperative Complications - etiology
Prediction models
Prognosis
Regression analysis
Retrospective Studies
Risk assessment
Risk factors
Tumors
Vision Disorders - etiology
Visual Acuity - physiology
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Summary:Objective The surgical treatment of optic pathway gliomas (OPG) remains controversial, with visual outcomes often unpredictable. The present study explored surgical and clinical factors influencing visual acuity (VA) after OPG treatment and developed anatomical subtypes correlated with clinical symptoms. Methods Children with OPG who underwent initial partial tumor resection at Beijing Tiantan Hospital from January 2011 to December 2022 were retrospectively analyzed. Multivariate logistic regression and random forest analyses were performed to identify risk factors for post-treatment VA deterioration and a decision tree model was created based on significant factors. Results A total of 140 patients were enrolled. Multivariate logistic regression analysis identified surgical approach and initial VA as independent predictors of post-treatment VA deterioration ( P  
ISSN:0167-594X
1573-7373
1573-7373
DOI:10.1007/s11060-024-04802-3