Self-Assembled BODIPY@Au Core-Shell Structures for Durable Neuroprotective Phototherapy

BODIPY analogs are promising photosensitizers for molecular phototherapy; however, they exhibit high dark cytotoxicity and limited singlet oxygen generation capacity. In this study, we developed self-assembled core-shell nanophotosensitizers by linking a bipyridine group to BODIPY (Bpy-BODIPY) and p...

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Bibliographic Details
Published in:Chembiochem : a European journal of chemical biology 2024-10, p.e202400562
Main Authors: Kong, Kien Voon, Wu, Melody Cai-Syaun, Wei, Jack Hau-Ting, Fan, Ricky Yu-Syun, Sim, Eng Zhi, Yong, Ken-Tye, Gong, Tianxun
Format: Article
Language:English
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Summary:BODIPY analogs are promising photosensitizers for molecular phototherapy; however, they exhibit high dark cytotoxicity and limited singlet oxygen generation capacity. In this study, we developed self-assembled core-shell nanophotosensitizers by linking a bipyridine group to BODIPY (Bpy-BODIPY) and promoting J-aggregation on gold nanourchins. This design enhances photostability and reduces the energy gap between the lowest singlet excited state and the lower triplet state, facilitating efficient singlet oxygen production. Notably, Bpy-BODIPY@Au significantly suppresses tau protein aggregation and enhances neuroprotective action, even in the presence of a phosphatase inhibitor. This work broadens the application of BODIPY chemistry to nanoagents for neuroprotective therapy.
ISSN:1439-4227
1439-7633
1439-7633
DOI:10.1002/cbic.202400562