The C-reactive protein-albumin-lymphocyte (CALLY) index is a useful predictor of postoperative complications in patients with a colonic stent for obstructive colorectal cancer: a Japanese multicenter study

• Published in: Surgery today (Tokyo, Japan) Japan), 2024-08
• Main Authors: Shiraishi, Toshio, Nonaka, Takashi, Tominaga, Tetsuro, Takamura, Yuma, Oishi, Kaido, Hashimoto, Shintaro, Noda, Keisuke, Ono, Rika, Hisanaga, Makoto, Takeshita, Hiroaki, Ishii, Mitsutoshi, Oyama, Shosaburo, Ishimaru, Kazuhide, Kunizaki, Masaki, Sawai, Terumitsu, Matsumoto, Keitaro
• Format: Article
• Language: English
• ISSN: 1436-2813; 1436-2813
• DOI: 10.1007/s00595-024-02924-9

The C-reactive protein-albumin-lymphocyte (CALLY) index is a novel score that offers a good reflection of nutritional status, inflammatory response, and immune system status. The CALLY index is reported to correlate with the prognosis of various carcinomas. The purpose of the present study was to investigate the association between the CALLY index and the short-term prognosis of obstructive colorectal cancer managed with a colonic stent. The subjects of this retrospective study were 263 patients who underwent colorectal resection after colonic stenting for obstructive colorectal cancer between 2016 and 2023. Patients were classified into a group with a low CALLY index (CALLY-L group, n = 85) and a group with a high (CALLY-H group, n = 178) CALLY index. The CALLY-L group had greater blood loss (53 mL vs 20 mL, p = 0.002) and higher poor performance status (PS3; 20% vs 10.1%, p = 0.033), open surgery (21.2% vs 7.3%, p = 0.001), distant metastases (41.2% vs 20.8%, p = 0.01), and postoperative complications (30.6% vs. 18.5%, p = 0.039) than the CALLY-H group. Multivariate analysis identified a prolonged operative time (odds ratio 1.983, 95% confidence interval 1.013-3.881; p = 0.045), greater blood loss (odds ratio 2.572, 95% confidence interval 1.291-5.129; p = 0.007) and a low CALLY index (odds ratio 1.961, 95% confidence interval 1.013-3.795; p = 0.045) as independent predictors of complications. The CALLY index may be a useful predictor of postoperative complications of obstructive colorectal cancer.