Diffuse alveolar hemorrhage in patients with systemic lupus erythematosus: data from the Spanish society of rheumathology Lupus Register (RELESSER)

• Published in: Rheumatology international 2024-11, Vol.44 (11), p.2445-2455
• Main Authors: Garcia-Villanueva, María Jesús, Garrote-Corral, Sandra, Pego-Reigosa, Jose María, Jiménez Otero, Norman, Uriarte Isazelaia, Esther, Olivé Marqué, Alejandro, Sangüesa Gómez, Clara, Freire González, Mercedes, Aurrecoechea Aguinaga, Elena, Raya Álvarez, Enrique, Tomero Muriel, Eva, Montilla Morales, Carlos, Galindo Izquierdo, María, Calvo-Alén, Jaime, Menor-Almagro, Raúl, Serrano Benavente, Belén, Martinez-Barrio, Julia, Hernández-Beriain, Jose Angel, Ibañez Barceló, Mónica, Bonilla Hernan, Gema, Rosas, Jose, Salgado Pérez, Eva, Fernández-Nebro, Antonio, Rua-Figueroa, Iñigo
• Format: Article
• Language: English
• Subjects: Adult; Cyclophosphamide - therapeutic use; Female; Glucocorticoids - therapeutic use; Hemorrhage - epidemiology; Hemorrhage - etiology; Humans; Hypoxemia; Immunosuppressive Agents - therapeutic use; Lung Diseases - epidemiology; Lung Diseases - etiology; Lung Diseases - therapy; Lupus; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - epidemiology; Male; Medicine; Medicine & Public Health; Middle Aged; Mortality; Observational Research; Plasmapheresis; Pulmonary Alveoli - pathology; Registries; Rheumatology; Spain - epidemiology; Young Adult
• ISSN: 1437-160X; 0172-8172; 1437-160X
• DOI: 10.1007/s00296-024-05684-4

Introduction:  Diffuse alveolar hemorrhage (DAH) is a rare complication with high mortality in patients with systemic lupus erythematosus (SLE). Early diagnosis and treatment are essential to improve patient prognosis. To determine the characteristics of patients with DAH and their mortality in a Spanish cohort of patients with SLE. Methods:  Patients from the RELESSER (Spanish Society of Rheumatology Lupus Register) who had had at least one confirmed episode of DAH were included. Epidemiological, clinical, and laboratory characteristics were analyzed. Results:  4024 patients were included in the RELESSER register, 37 (0.9%), had at least one recorded episode of DAH. Only further data for 14 patients could be analyzed. In total, 92.9% were women, and for 4 (28.6%) DAH coincided with the debut of SLE. More than 80% of patients had renal involvement and thrombocytopenia. The most frequent manifestations were dyspnea (85.7%) and hypoxemia (100%), with the classic triad of hemoptysis, anemia and pulmonary infiltrates, appearing in 6 (46.2%) patients. The most frequently used treatments were glucocorticoids (85.7%) and cyclophosphamide (69.2%); plasmapheresis was utilized in 5 patients (35.7%) and 8, (57.1%) received intravenous immunoglobulins; 12 (85.7%) patients required admission to the ICU and 5 (35.7%) died. Tobacco use, history of lupus nephritis (LN), concomitant infection, and treatment with cyclophosphamide were more frequent in patients who died. Conclusions:  DAH is rare in patients with SLE; in up to one-third of patients, it may appear at the onset of the disease. Some factors, such as smoking, a history of LN, treatment with cyclophosphamide, or concomitant infection, are more prevalent in patients with an unfavorable outcome.