An RNAi screen for ribosome biogenesis genes required for Drosophila border cell collective migration

Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found...

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Bibliographic Details
Published in:microPublication biology 2024, Vol.2024
Main Authors: Burghardt, Emily, McDonald, Jocelyn A
Format: Article
Language:English
Online Access:Get full text
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Summary:Ribosome biogenesis is critical for the proper production of proteins in cells and has emerged as a regulator of cell invasion and migration in development and in cancer. The border cells form a collective that invades and migrates through the surrounding tissue during oogenesis. We previously found that a significant number of ribosome biogenesis genes are differentially expressed from early to late migration stages. Here, we performed a small-scale RNAi screen of a subset of these ribosome genes. Knockdown of seven genes disrupted border cell migration, thus revealing a role for ribosome biogenesis genes in regulating collective cell migration.
ISSN:2578-9430
2578-9430
DOI:10.17912/micropub.biology.001292