Myocardial Recovery in Cardiogenic Shock

The overarching goal of cardiogenic shock (CS) therapy is ensuring long-term survival. In recent years, increasing emphasis has been placed on analyzing mechanisms to improve outcomes in CS. This includes averting in-hospital mortality, modifying the disease process by promoting heart recovery while...

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Bibliographic Details
Published in:Methodist DeBakey cardiovascular journal 2024, Vol.20 (4), p.64-75
Main Authors: John, Kevin, Khalif, Adnan, Tsukashita, Masaki, Kanwar, Manreet K
Format: Article
Language:English
Subjects:
Animals
Humans
Recovery of Function
Risk Factors
Shock, Cardiogenic - diagnosis
Shock, Cardiogenic - etiology
Shock, Cardiogenic - mortality
Shock, Cardiogenic - physiopathology
Shock, Cardiogenic - therapy
Time Factors
Treatment Outcome
Ventricular Function, Left
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Summary:The overarching goal of cardiogenic shock (CS) therapy is ensuring long-term survival. In recent years, increasing emphasis has been placed on analyzing mechanisms to improve outcomes in CS. This includes averting in-hospital mortality, modifying the disease process by promoting heart recovery while avoiding multiorgan failure, and circumventing complications related to both CS and treatment strategies deployed to treat CS. Heart replacement therapies represent a viable strategy for long-term survival but are restricted to a small, select percentage of patients. In this review we focus on pathophysiology of the shock state, with an emphasis on addressing reversible etiologies contributing to the decompensated state, optimizing physiological factors for recovery, and identifying therapeutic targets to promote recovery. We also review the known predictors of myocardial recovery, regardless of the etiology of CS. Lastly, we highlight the current gaps in knowledge in this field and support additional high-quality studies focusing on myocardial recovery in CS.
ISSN:1947-6108
1947-6108
DOI:10.14797/mdcvj.1383