Impact of Frailty on Outcome of Older Patients With Non-ST Elevation Acute Myocardial Infarction Who Undergo Percutaneous Coronary Intervention

Frailty status is linked with a poorer clinical outcome, and patients with frailty are often less revascularized, even with percutaneous coronary intervention (PCI). We therefore sought to assess the impact of frailty on the clinical outcome of older patients with non-ST elevation acute myocardial i...

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Bibliographic Details
Published in:The American journal of cardiology 2024-11, Vol.230, p.41-46
Main Authors: Mele, Marco, Ragnatela, Ilaria, Romano, Matteo, Tabella, Erika, Rossi, Luciano Umberto, Mautone, Francesco, Mele, Antonietta, Liantonio, Antonella, Imbrici, Paola, Correale, Michele, Santoro, Francesco, Brunetti, Natale Daniele
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Aged
Aged, 80 and over
Angioplasty
Cardiology
Cardiovascular disease
Chronic fatigue syndrome
Coronary vessels
Dementia
Dementia disorders
Elderly
Electrocardiography
Female
Follow-Up Studies
Frail Elderly
Frailty
Frailty - complications
Frailty - epidemiology
Geriatric Assessment - methods
Health risks
Heart
Heart attacks
Humans
Hypotheses
Ischemia
Life expectancy
Male
Mortality
Myocardial infarction
Non-ST Elevated Myocardial Infarction - mortality
Non-ST Elevated Myocardial Infarction - surgery
NSTEMI
Observational studies
Older people
Patients
Percutaneous Coronary Intervention
Prospective Studies
Regression analysis
Risk Factors
Survival Rate - trends
Treatment Outcome
Vein & artery diseases
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Summary:Frailty status is linked with a poorer clinical outcome, and patients with frailty are often less revascularized, even with percutaneous coronary intervention (PCI). We therefore sought to assess the impact of frailty on the clinical outcome of older patients with non-ST elevation acute myocardial infarction (NSTEMI) who underwent PCI. We prospectively enrolled 141 consecutive older patients (>75 years) admitted for NSTEMI; 104 patients underwent PCI (35 with frailty, 69 without frailty), and 37 were not revascularized (22 with frailty, 15 without). Patients with frailty were older, less frequently male, more affected by dementia and severe left ventricular dysfunction, and less treated with PCI; patients treated with PCI were younger and less affected by dementia. Thirty-day mortality rates were proportionally higher, from 3% in patients without frailty treated with PCI, to 7% in patients without frailty not treated with PCI, 17% in patients with frailty treated with PCI, and 48% in patients with frailty not treated with PCI (p
ISSN:0002-9149
1879-1913
1879-1913
DOI:10.1016/j.amjcard.2024.08.016