The mediating role of depression in the association between socioeconomic status and cardiovascular disease: A nationwide cross-sectional study from NHANES 2005–2018

Disparities in socioeconomic status (SES) are associated with an increased risk of cardiovascular disease (CVD). Depression is a highly prevalent cardiovascular risk factor among individuals with low SES. The present study aimed to gain a better understanding of the association between SES and CVD b...

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Bibliographic Details
Published in:Journal of affective disorders 2024-12, Vol.366, p.466-473
Main Authors: Hua, Jinghai, Shen, Ruihuan, Guo, Xuantong, Yu, Ling, Qiu, Minzi, Ma, Lihong, Peng, Xiaoping
Format: Article
Language:English
Subjects:
Cardiovascular disease
Depression
Mediation analyses
Socioeconomic status
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Summary:Disparities in socioeconomic status (SES) are associated with an increased risk of cardiovascular disease (CVD). Depression is a highly prevalent cardiovascular risk factor among individuals with low SES. The present study aimed to gain a better understanding of the association between SES and CVD by examining the mediating effects of depression. 30,127 participants, 50.77 % female, with a mean age of 47.37 years from the National Health and Nutrition Examination Survey (NHANES) 2005–2018, were included. Weighted multivariable logistic regression analyses estimated the association between SES and CVD. Mediation analyses tested the mediating effects of depression. The multivariable-adjusted odds ratio (OR) of high SES for CVD was 0.42 (95 % confidence interval (CI): 0.36, 0.50; P 
ISSN:0165-0327
1573-2517
1573-2517
DOI:10.1016/j.jad.2024.08.145