Suaedamas A‐D: Four New Compounds from the Aerial Parts of Suaeda maritima with Inhibition of NO Production Activity

Four new compounds, suaedamas A–D (1–4), and seven known ones (5–11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR, experimental and calculated ECD spectra. Compounds 1–6 inhibited nitric oxide production in LPS...

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Published in:Chemistry & biodiversity 2024-12, Vol.21 (12), p.e202401787-n/a
Main Authors: Trang, Bui Thi Nha, Anh, Bui Thi Mai, Mai, Nguyen Thi, Cuc, Nguyen Thi, Huyen, Le Thi, Nga, Nhu Thi Hang, Kiem, Phan Van, Tai, Bui Huu
Format: Article
Language:English
Subjects:
Amaranthaceae
Animals
Chenopodiaceae - chemistry
Dexamethasone
Dexamethasone - chemistry
Dexamethasone - pharmacology
Dose-Response Relationship, Drug
Lipopolysaccharides - antagonists & inhibitors
Lipopolysaccharides - pharmacology
Mice
Molecular Conformation
Molecular Structure
Nitric oxide
Nitric Oxide - antagonists & inhibitors
Nitric Oxide - biosynthesis
Nitric Oxide - metabolism
NMR
NO inhibitory activity
Nuclear magnetic resonance
Plant Components, Aerial - chemistry
Plant Components, Aerial - metabolism
Polyacetylene
RAW 264.7 Cells
Structure-Activity Relationship
Suaeda maritima
Suaeda maritime
Suaedama
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Summary:Four new compounds, suaedamas A–D (1–4), and seven known ones (5–11) were isolated from the aerial parts of Suaeda maritima. Their chemical structures were evaluated by the IR, HR‐ESI‐MS, 1D‐, and 2D‐NMR, experimental and calculated ECD spectra. Compounds 1–6 inhibited nitric oxide production in LPS activated RAW 264.7 cells with IC50 values ranging from 29.3 to 85.5 μM, compared to that of the positive control compound, dexamethasone, which showed IC50 value of 13.4 μM.
ISSN:1612-1872
1612-1880
1612-1880
DOI:10.1002/cbdv.202401787