Supramolecular materials constructed from synthetic glycopeptides via aqueous self-assembly and their bioapplications in immunotherapy

Synthetic glycopeptides capable of self-assembly in aqueous environments form a range of supramolecular nanostructures, such as nanoparticles and nanofibers, owing to their amphiphilic nature and the diverse structures of the saccharides introduced. These glycopeptide-based supramolecular materials...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-09, Vol.22 (36), p.7287-7306
Main Authors: Sugiura, Shintaro, Ikeda, Masato
Format: Article
Language:English
Subjects:
Animals
Aqueous environments
Biocompatibility
Carbohydrates
Displays
Glycopeptides
Glycopeptides - chemical synthesis
Glycopeptides - chemistry
Humans
Immunomodulation
Immunotherapy
Macromolecular Substances - chemical synthesis
Macromolecular Substances - chemistry
Macromolecular Substances - pharmacology
Nanoparticles
Saccharides
Self-assembly
Water - chemistry
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Summary:Synthetic glycopeptides capable of self-assembly in aqueous environments form a range of supramolecular nanostructures, such as nanoparticles and nanofibers, owing to their amphiphilic nature and the diverse structures of the saccharides introduced. These glycopeptide-based supramolecular materials are promising for immunotherapy applications because of their biocompatibility and multivalent saccharide display, which enhances lectin-saccharide interactions. This review highlights recent advances in the molecular design of synthetic glycopeptide-based supramolecular materials and their use as immunomodulatory agents.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob01116c