Autologous exosomes loaded with a rationally designed photosensitizer for enhanced photodynamic therapy

We present generalizing statistical surrogate models to select an optimized photosensitizer, TPP, which is subsequently loaded into autologous exosomes by ultrasonic mixing to achieve tumor targeting with enhanced therapeutic efficacy by photodynamic therapy (PDT). This work contributes to the explo...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-09, Vol.6 (74), p.118-1183
Main Authors: Qian, Yuhan, Li, Chong, Gao, Ji, Wang, Shuxian, Wu, Xue, Wei, Luyao, Zha, Menglei, Shi, Yuxin, Kang, Tianyi, Li, Kai
Format: Article
Language:English
Subjects:
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Cell Line, Tumor
Cell Survival - drug effects
Exosomes - chemistry
Exosomes - metabolism
Humans
Mice
Neoplasms - drug therapy
Neoplasms - therapy
Photochemotherapy
Photodynamic therapy
Photosensitizing Agents - chemistry
Photosensitizing Agents - pharmacology
Porphyrins - chemistry
Porphyrins - pharmacology
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Summary:We present generalizing statistical surrogate models to select an optimized photosensitizer, TPP, which is subsequently loaded into autologous exosomes by ultrasonic mixing to achieve tumor targeting with enhanced therapeutic efficacy by photodynamic therapy (PDT). This work contributes to the exploration of PDT enhancement strategies, and provides new prospects for using autologous exosomes as a delivery system. We present generalizing statistical surrogate models to optimize photosensitizer selection and enhance photodynamic therapy efficacy by encapsulating it into autologous exosomes.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc02168a