Effect of post thrombolytic intracerebral hemorrhage volume on 90-day outcomes in acute ischemic stroke patients

Post thrombolytic intracerebral hemorrhage (ICH) is associated with higher rate of death or disability in acute ischemic stroke patients. We investigated the relationship between post thrombolytic ICH volume and change in volume and death or disability at 90 days in acute ischemic stroke patients. W...

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Bibliographic Details
Published in:Journal of stroke and cerebrovascular diseases 2024-11, Vol.33 (11), p.107962, Article 107962
Main Authors: Gillani, Syed A, Ma, Xiaoyu, Huang, Yilun, Bains, Navpreet K., Fakih, Rami, Siddiq, Farhan, French, Brandi R., Gomez, Camilo R., Lyden, Patrick D., Qureshi, Adnan I
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Alteplase
Cerebral Hemorrhage - diagnostic imaging
Cerebral Hemorrhage - drug therapy
Death or disability
Disability Evaluation
Female
Fibrinolytic Agents - administration & dosage
Fibrinolytic Agents - adverse effects
Functional Status
Humans
ICH outcomes
Ischemic Stroke - diagnostic imaging
Ischemic Stroke - drug therapy
Ischemic Stroke - physiopathology
Ischemic Stroke - therapy
Magnetic Resonance Imaging
Male
Middle Aged
post thrombolytic ICH
Recovery of Function
Risk Factors
Stroke
Thrombectomy - adverse effects
Thrombolysis
Thrombolytic Therapy - adverse effects
Time Factors
Tissue Plasminogen Activator - administration & dosage
Tissue Plasminogen Activator - adverse effects
TNK
Treatment Outcome
UW-mRS
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Summary:Post thrombolytic intracerebral hemorrhage (ICH) is associated with higher rate of death or disability in acute ischemic stroke patients. We investigated the relationship between post thrombolytic ICH volume and change in volume and death or disability at 90 days in acute ischemic stroke patients. We analyzed 110 patents recruited in the Safety Evaluation of 3K3A-APC in Ischemic Stroke (RHAPSODY) trial who received intravenous tissue plasminogen activator (tPA) followed by mechanical thrombectomy (if indicated) and 3K3A-APC or placebo. ICH volume was measured at Day 2 and Day 7 using susceptibility weighted sequence (SWI) on magnetic resonance imaging (MRI). We also calculated the post thrombolytic ICH volume change between Day 2 and Day 7. Outcomes were determined by using utility weighted modified Rankin scale (UW-mRs) at 90-days, Outcomes were determined by using utility weighted modified Rankin scale (UW-mRS) at 90 days. To minimize interpretation bias, outcome assessors were blinded to the treatment allocation and clinical data.We adjusted for age, gender, National Institutes of Health Stroke Scale (NIHSS) score (
ISSN:1052-3057
1532-8511
1532-8511
DOI:10.1016/j.jstrokecerebrovasdis.2024.107962