Pharmacological Modulation of Cognitive Test Solution in Mice of Two Genotypes

Mice of two strains selected for successful solution of “object permanence” test and for lack of such solution demonstrated the differential reaction to injections of two drugs. The effects of injections of atomoxetine. which blocks the noradrenaline reuptake, and of ‘non-benzodiazepine” anxiolytic...

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Bibliographic Details
Published in:Doklady. Biochemistry and biophysics 2024-10, Vol.518 (1), p.417-419
Main Authors: Perepelkina, O. V., Poletaeva, I. I.
Format: Article
Language:English
Subjects:
Benzodiazepines
Biochemistry
Biological and Medical Physics
Biomedical and Life Sciences
Biophysics
Genotypes
Life Sciences
Molecular Biology
Norepinephrine
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Summary:Mice of two strains selected for successful solution of “object permanence” test and for lack of such solution demonstrated the differential reaction to injections of two drugs. The effects of injections of atomoxetine. which blocks the noradrenaline reuptake, and of ‘non-benzodiazepine” anxiolytic afobazol was different. The success of solutions increased in mice selected for this test “non-solution”: and decreased or was inefficient in mice, selected for successful solution of object permanence cognitive test.
ISSN:1607-6729
1608-3091
1608-3091
DOI:10.1134/S1607672924701096