Loading…

Incorporation mutational profile might reduce the importance of blast count in prognostication of low-risk myelodysplastic syndromes

Addition of molecular data to prognostic models has improved risk stratification of myelodysplastic neoplasms (MDS). However, the role of molecular lesions, particularly in the group of low-risk disease (LR-MDS), is uncertain. We evaluated a set of 227 patients with LR-MDS. Overall survival (OS) and...

Full description

Saved in:
Bibliographic Details
Published in:British journal of haematology 2024-11, Vol.205 (5), p.1765-1772
Main Authors: García-Culebras, Marta, Alcalde, Patricia, Márquez-Malaver, Francisco J, Carrillo, Estrella, Soria, Elena, Prats, Concepción, Morales, Rosario, Vargas, María T, Pérez-Simón, Jose Antonio, Falantes, Jose F
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Addition of molecular data to prognostic models has improved risk stratification of myelodysplastic neoplasms (MDS). However, the role of molecular lesions, particularly in the group of low-risk disease (LR-MDS), is uncertain. We evaluated a set of 227 patients with LR-MDS. Overall survival (OS) and probability of leukaemic progression were the main endpoints. RUNX1 was associated with lower OS and SF3B1 with a reduced risk of death (HR: 1.7, 95% CI, 1.1-2.9; p = 0.05; and HR: 0.23, 95% CI 0.1-0.5; p 
ISSN:0007-1048
1365-2141
1365-2141
DOI:10.1111/bjh.19714