Management of Alzheimer's disease and related neurotoxic pathologies: Role of thiamine, pyridoxine and cobalamin

Alzheimer's disease (AD) remains one of the most debilitating disease and most common neurological disorder in the world at large. However, with many years of multiple research and billions of dollars invested for the purpose of research, not many therapeutic options exist for the management of...

Full description

Saved in:
Bibliographic Details
Published in:European journal of pharmacology 2024-11, Vol.982, p.176958, Article 176958
Main Authors: Ekundayo, Bidemi Emmanuel, Adewale, Olusola Bolaji, Obafemi, Blessing Ariyo, Afolabi, Olakunle Bamikole, Obafemi, Tajudeen Olabisi
Format: Article
Language:English
Subjects:
Alzheimer's disease
Cobalamin
Pyridoxine
Thiamine
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Alzheimer's disease (AD) remains one of the most debilitating disease and most common neurological disorder in the world at large. However, with many years of multiple research and billions of dollars invested for the purpose of research, not many therapeutic options exist for the management of this disease. As at 2023, the number has only increased to 7, one of which is a combination of two existing therapies. However, research has continued still in the search for a cure. The roles and functions of thiamine, pyridoxine and cobalamin in the proper function of the nervous system has been well researched over time and their role in the management of neurological diseases have been of interest in the last decade. This review describes the roles of the aforementioned chemicals in the management of different models of AD and AD-like pathologies as mono-therapeutic agents and prospective adjuvant for combination therapy.
ISSN:0014-2999
1879-0712
1879-0712
DOI:10.1016/j.ejphar.2024.176958