Plaque enhancement of middle cerebral artery and pre-stroke diet are associated with prognosis of subacute ischemic stroke: A prospective high-resolution MR vessel wall imaging study

•Plaque characteristics based on HR-VWI are significantly associated with ischemic stroke outcomes at 3 months.•Combining NIHSS score, Mediterranean diet score, and plaque enhancement ratio improves the accuracy of outcome prediction on subacute ischemic stroke at 3 months.•Improving diet and monito...

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Published in:European journal of radiology 2024-11, Vol.180, p.111693, Article 111693
Main Authors: Zheng, Wenqiao, Yan, Haili, Tian, Dawei, Li, Yan, Wang, Le, Lei, Ying, Wang, Bin, Wang, Yongfang, Yang, Guoqiang, Wang, Xiaochun
Format: Article
Language:English
Subjects:
Aged
Female
High-resolution MR vessel wall imaging
Humans
Intracranial atherosclerosis
Ischemic Stroke - diagnostic imaging
Ischemic stroke outcomes
Magnetic Resonance Angiography - methods
Male
Mediterranean diet
Middle Aged
Middle Cerebral Artery - diagnostic imaging
Plaque, Atherosclerotic - diagnostic imaging
Prognosis
Prospective Studies
Reproducibility of Results
Sensitivity and Specificity
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Summary:•Plaque characteristics based on HR-VWI are significantly associated with ischemic stroke outcomes at 3 months.•Combining NIHSS score, Mediterranean diet score, and plaque enhancement ratio improves the accuracy of outcome prediction on subacute ischemic stroke at 3 months.•Improving diet and monitoring plaque may contribute to better short-term clinical outcomes. To explore the value of middle cerebral artery (MCA) plaque characteristics in predicting the outcomes of subacute ischemic stroke and the incremental value of the previous diet on predictive performance. One hundred and thirty-seven subacute ischemic stroke patients attributed to MCA plaques were included and analyzed in this prospective study. The National Institute of Health Stroke Scale (NIHSS) score, Mediterranean Diet Adherence Screener (MEDAS) score, and other clinical data were assessed. The plaque area, degree of stenosis, plaque burden, enhancement ratio, remodeling type, and intraplaque hemorrhage were measured using high-resolution MR vessel wall imaging (HR-VWI). Multivariable logistic regression analysis and receiver operating characteristic curve analysis were performed to assess the predictive performance of clinical and plaque characteristics for subacute ischemic stroke outcomes at 3 months. Patients with poor outcomes exhibited high NIHSS scores, and low MEDAS scores (P
ISSN:0720-048X
1872-7727
1872-7727
DOI:10.1016/j.ejrad.2024.111693