The prognostic role of cardiopulmonary exercise testing in obesity

• Published in: Diabetes, obesity & metabolism obesity & metabolism, 2024-11, Vol.26 (11), p.5251-5260
• Main Authors: Borghi‐Silva, Audrey, Vainshelboim, Baruch, Luz Goulart, Cássia, Arena, Ross, Myers, Jonathan
• Format: Article
• Language: English
• Subjects: Adult; Carbon dioxide; Cardiorespiratory fitness; Cardiorespiratory Fitness - physiology; Exercise Test - methods; Female; Humans; Male; Medical prognosis; metabolic syndrome; Middle Aged; Mortality; Obesity; Obesity - complications; Obesity - mortality; Obesity - physiopathology; Oxygen Consumption - physiology; Physical fitness; Prognosis; Regression analysis; Survival; ventilatory efficiency; ventilatory power
• ISSN: 1462-8902; 1463-1326; 1463-1326
• DOI: 10.1111/dom.15877

Aim Poor cardiorespiratory fitness has been suggested to increase the risk of chronic diseases in obesity. We investigated the ability of key variables from cardiopulmonary exercise testing (CPET) to predict all‐cause mortality in an obese cohort. Methods The sample included 469 participants of both sexes (mean age 40 ± 13 years) who underwent a CPET for clinical reasons between 1 March 2009 and 1 December 2023. All‐cause mortality was the prognostic endpoint. A receiver operating characteristic analysis was performed to establish optimal cut‐points for CPET variables. Kaplan–Meier and Cox regression analyses were used to determine the association between CPET variables and all‐cause mortality. Results There were 46 deaths during a mean follow‐up period of 69 ± 48 months, resulting in an annual mortality rate of 2%. Despite the sample being made up of mostly women (70%), there were more deaths in men (18 vs. 6%, p