Multivalent Pt/Ti3C2Tx Nanocomposite-Based Immunochromatographic Sensor for Colorimetric/Temperature/Pressure Trimodal Detection

Multimodal immunochromatographic sensors (ICSs) have acquired extensive attention since they not only provide reliable results by comparing the different output signals but also flexibly respond to various application environments. Herein, an ICS with triple signal outputs including colorimetry, tem...

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Bibliographic Details
Published in:Analytical chemistry (Washington) 2024-09, Vol.96 (37), p.15074-15080
Main Authors: Xue, Jinxia, Li, Jizhou, Ma, Yuchan, Obaid, Essam A. M. S., Ouyang, Hui, Guo, Ting, Fu, Zhifeng
Format: Article
Language:English
Subjects:
Catalase
Chlorothalonil
Colorimetry
Detection limits
Hydrogen peroxide
Immunoassay
Infrared analysis
Nanocomposites
Nanoparticles
Photothermal conversion
Platinum
Pressure
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Summary:Multimodal immunochromatographic sensors (ICSs) have acquired extensive attention since they not only provide reliable results by comparing the different output signals but also flexibly respond to various application environments. Herein, an ICS with triple signal outputs including colorimetry, temperature, and pressure was developed for sensitive detection of chlorothalonil. The multivalent Pt/Ti3C2Tx nanoparticles as signal tags were facilely synthesized by loading PtNPs onto single-layer Ti3C2Tx nanosheets with high surface area. The acquired Pt/Ti3C2TxNPs accelerated the rate-limiting step of the aerogenesis reaction of H2O2 for producing intensive pressure signals due to their significant catalase-mimic activity. Meanwhile, they showed desirable photothermal conversion efficiency in the near-infrared region for producing significant temperature signals. Furthermore, their deep color also allowed facile colorimetry by using the naked eye. Based on a competitive immunoassay, chlorothalonil was detected as a model analyte on this trimodal ICS platform. The detection limits for pressure, temperature, and colorimetric modes were 0.04, 0.09, and 5 ng mL–1, respectively. The recoveries for detecting chlorothalonil supplemented in Astragalus and Honeysuckle with pressure mode were 84.0–110% and 108–114%, respectively. Therefore, the ICS presented a portable, sensitive, accurate, and flexible multimodal strategy suitable for point-of-care testing.
ISSN:0003-2700
1520-6882
1520-6882
DOI:10.1021/acs.analchem.4c04168