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Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study
•Clinicians should pay attention to several influencing factors for RLN injury.•Safe TEG-D thresholds were 2.2 mm for benign nodules and 4.9 mm for malignant ones.•TEG-D was an independent risk factor for recovery time of hoarseness. This study aimed to investigate the risk factors for recurrent lar...
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| Published in: | Radiotherapy and oncology 2024-11, Vol.200, p.110516, Article 110516 |
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| creator | Xu, Ming-hong Dou, Jian-ping Guo, Mo-han Yi, Wen-qi Han, Zhi-yu Liu, Fang-yi Yu, Jie Cheng, Zhi-gang Yu, Xiao-ling Wang, Hui Bai, Nan Wang, Shu-rong Yu, Ming-an Liang, Ping Chen, Lei |
| description | •Clinicians should pay attention to several influencing factors for RLN injury.•Safe TEG-D thresholds were 2.2 mm for benign nodules and 4.9 mm for malignant ones.•TEG-D was an independent risk factor for recovery time of hoarseness.
This study aimed to investigate the risk factors for recurrent laryngeal nerve (RLN) injury after microwave ablation (MWA) of thyroid nodules and to identify factors influencing the recovery time of post-procedure hoarseness.
We retrospectively analyzed data from patients who underwent MWA for thyroid nodules at five hospitals between November 2018 and July 2022. Patients were divided into malignant and benign nodule groups. Variables analyzed included nodule size and location, the shortest distance from nodules to the thyroid capsule and tracheoesophageal groove (TEG-D), and ablation parameters. Univariate and multivariate analyses were performed to identify risk factors. Kaplan-Meier and Cox analyses were used to evaluate the recovery time of hoarseness after MWA.
The study included 1,216 patients (mean age 44 ± 12 [SD] years; 901 women) with 602 malignant nodules and 614 benign nodules. The posterior capsule distance (PCD) and TEG-D were identified as independent influencing factors for hoarseness in all patients (P = 0.014, OR = 0.068; P |
| doi_str_mv | 10.1016/j.radonc.2024.110516 |
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| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3099807348</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0167814024034947</els_id><sourcerecordid>3099807348</sourcerecordid><originalsourceid>FETCH-LOGICAL-c241t-2cb765137015f109c36d053ca3cf7851bfaac35255dec6305f01f732234ce2403</originalsourceid><addsrcrecordid>eNp9kNFqFTEQhoMo9lh9A5FcerPHSbLZ7HohlKK2UBBEr0NOMtEcd5OaZFvO25uy1UuvBobvn-H_CHnNYM-ADe-O-2xcinbPgfd7xkCy4QnZsVFNHYyjekp2DVPdyHo4Iy9KOQIAB6GekzMxcTaMvN-R9DWUX9QbW1Mu1KdMM9o1Z4yVziaf4g80M42Y75CGeFzzqQ26BJvTvWk7c5hNDSnS5Gn9ecopOBqTW2cs7-kFXda5BtuOYaalru70kjzzZi746nGek--fPn67vOpuvny-vry46SzvWe24PahBMqGASc9gsmJwIIU1wno1SnbwxlghuZQO7SBAemBeCc5Fb5H3IM7J2-3ubU6_VyxVL6FYnGcTMa1FC5imEZTox4b2G9o6lZLR69scltZdM9APqvVRb6r1g2q9qW6xN48f1sOC7l_or9sGfNgAbD3vAmZdbMBo0YXmuGqXwv8__AFhY5Jv</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3099807348</pqid></control><display><type>article</type><title>Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study</title><source>ScienceDirect Freedom Collection</source><creator>Xu, Ming-hong ; Dou, Jian-ping ; Guo, Mo-han ; Yi, Wen-qi ; Han, Zhi-yu ; Liu, Fang-yi ; Yu, Jie ; Cheng, Zhi-gang ; Yu, Xiao-ling ; Wang, Hui ; Bai, Nan ; Wang, Shu-rong ; Yu, Ming-an ; Liang, Ping ; Chen, Lei</creator><creatorcontrib>Xu, Ming-hong ; Dou, Jian-ping ; Guo, Mo-han ; Yi, Wen-qi ; Han, Zhi-yu ; Liu, Fang-yi ; Yu, Jie ; Cheng, Zhi-gang ; Yu, Xiao-ling ; Wang, Hui ; Bai, Nan ; Wang, Shu-rong ; Yu, Ming-an ; Liang, Ping ; Chen, Lei</creatorcontrib><description>•Clinicians should pay attention to several influencing factors for RLN injury.•Safe TEG-D thresholds were 2.2 mm for benign nodules and 4.9 mm for malignant ones.•TEG-D was an independent risk factor for recovery time of hoarseness.
This study aimed to investigate the risk factors for recurrent laryngeal nerve (RLN) injury after microwave ablation (MWA) of thyroid nodules and to identify factors influencing the recovery time of post-procedure hoarseness.
We retrospectively analyzed data from patients who underwent MWA for thyroid nodules at five hospitals between November 2018 and July 2022. Patients were divided into malignant and benign nodule groups. Variables analyzed included nodule size and location, the shortest distance from nodules to the thyroid capsule and tracheoesophageal groove (TEG-D), and ablation parameters. Univariate and multivariate analyses were performed to identify risk factors. Kaplan-Meier and Cox analyses were used to evaluate the recovery time of hoarseness after MWA.
The study included 1,216 patients (mean age 44 ± 12 [SD] years; 901 women) with 602 malignant nodules and 614 benign nodules. The posterior capsule distance (PCD) and TEG-D were identified as independent influencing factors for hoarseness in all patients (P = 0.014, OR = 0.068; P < 0.001, OR = 0.005; AUC = 0.869). TEG-D was a significant risk factor for hoarseness, with safe thresholds identified at 4.9 mm for malignant nodules and 2.2 mm for benign nodules. Among patients who developed hoarseness, those in the close-distance group (TEG-D≤2 mm) had a longer recovery time compared to the distant-distance group. TEG-D was an independent factor influencing recovery time (P = 0.008, HR = 11.204).
Clinicians should consider several factors, particularly TEG-D and PCD, when assessing the risk of RLN injury before MWA. TEG-D was a vital independent factor influencing recovery time.
Clinicians should pay attention to several influencing factors for RLN injury before MWA and TEG-D was an independent influencing factor for recovery time of hoarseness after MWA.</description><identifier>ISSN: 0167-8140</identifier><identifier>ISSN: 1879-0887</identifier><identifier>EISSN: 1879-0887</identifier><identifier>DOI: 10.1016/j.radonc.2024.110516</identifier><identifier>PMID: 39216824</identifier><language>eng</language><publisher>Ireland: Elsevier B.V</publisher><subject>Ablation Techniques - adverse effects ; Ablation Techniques - methods ; Adult ; Female ; Hoarseness - etiology ; Humans ; Male ; Microwave ablation ; Microwaves - adverse effects ; Microwaves - therapeutic use ; Middle Aged ; Recurrent laryngeal nerve ; Recurrent Laryngeal Nerve Injuries - etiology ; Retrospective Studies ; Risk factor ; Risk Factors ; Thyroid nodule ; Thyroid Nodule - pathology ; Thyroid Nodule - surgery</subject><ispartof>Radiotherapy and oncology, 2024-11, Vol.200, p.110516, Article 110516</ispartof><rights>2024 Elsevier B.V.</rights><rights>Copyright © 2024 Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c241t-2cb765137015f109c36d053ca3cf7851bfaac35255dec6305f01f732234ce2403</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39216824$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xu, Ming-hong</creatorcontrib><creatorcontrib>Dou, Jian-ping</creatorcontrib><creatorcontrib>Guo, Mo-han</creatorcontrib><creatorcontrib>Yi, Wen-qi</creatorcontrib><creatorcontrib>Han, Zhi-yu</creatorcontrib><creatorcontrib>Liu, Fang-yi</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Cheng, Zhi-gang</creatorcontrib><creatorcontrib>Yu, Xiao-ling</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Bai, Nan</creatorcontrib><creatorcontrib>Wang, Shu-rong</creatorcontrib><creatorcontrib>Yu, Ming-an</creatorcontrib><creatorcontrib>Liang, Ping</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><title>Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study</title><title>Radiotherapy and oncology</title><addtitle>Radiother Oncol</addtitle><description>•Clinicians should pay attention to several influencing factors for RLN injury.•Safe TEG-D thresholds were 2.2 mm for benign nodules and 4.9 mm for malignant ones.•TEG-D was an independent risk factor for recovery time of hoarseness.
This study aimed to investigate the risk factors for recurrent laryngeal nerve (RLN) injury after microwave ablation (MWA) of thyroid nodules and to identify factors influencing the recovery time of post-procedure hoarseness.
We retrospectively analyzed data from patients who underwent MWA for thyroid nodules at five hospitals between November 2018 and July 2022. Patients were divided into malignant and benign nodule groups. Variables analyzed included nodule size and location, the shortest distance from nodules to the thyroid capsule and tracheoesophageal groove (TEG-D), and ablation parameters. Univariate and multivariate analyses were performed to identify risk factors. Kaplan-Meier and Cox analyses were used to evaluate the recovery time of hoarseness after MWA.
The study included 1,216 patients (mean age 44 ± 12 [SD] years; 901 women) with 602 malignant nodules and 614 benign nodules. The posterior capsule distance (PCD) and TEG-D were identified as independent influencing factors for hoarseness in all patients (P = 0.014, OR = 0.068; P < 0.001, OR = 0.005; AUC = 0.869). TEG-D was a significant risk factor for hoarseness, with safe thresholds identified at 4.9 mm for malignant nodules and 2.2 mm for benign nodules. Among patients who developed hoarseness, those in the close-distance group (TEG-D≤2 mm) had a longer recovery time compared to the distant-distance group. TEG-D was an independent factor influencing recovery time (P = 0.008, HR = 11.204).
Clinicians should consider several factors, particularly TEG-D and PCD, when assessing the risk of RLN injury before MWA. TEG-D was a vital independent factor influencing recovery time.
Clinicians should pay attention to several influencing factors for RLN injury before MWA and TEG-D was an independent influencing factor for recovery time of hoarseness after MWA.</description><subject>Ablation Techniques - adverse effects</subject><subject>Ablation Techniques - methods</subject><subject>Adult</subject><subject>Female</subject><subject>Hoarseness - etiology</subject><subject>Humans</subject><subject>Male</subject><subject>Microwave ablation</subject><subject>Microwaves - adverse effects</subject><subject>Microwaves - therapeutic use</subject><subject>Middle Aged</subject><subject>Recurrent laryngeal nerve</subject><subject>Recurrent Laryngeal Nerve Injuries - etiology</subject><subject>Retrospective Studies</subject><subject>Risk factor</subject><subject>Risk Factors</subject><subject>Thyroid nodule</subject><subject>Thyroid Nodule - pathology</subject><subject>Thyroid Nodule - surgery</subject><issn>0167-8140</issn><issn>1879-0887</issn><issn>1879-0887</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kNFqFTEQhoMo9lh9A5FcerPHSbLZ7HohlKK2UBBEr0NOMtEcd5OaZFvO25uy1UuvBobvn-H_CHnNYM-ADe-O-2xcinbPgfd7xkCy4QnZsVFNHYyjekp2DVPdyHo4Iy9KOQIAB6GekzMxcTaMvN-R9DWUX9QbW1Mu1KdMM9o1Z4yVziaf4g80M42Y75CGeFzzqQ26BJvTvWk7c5hNDSnS5Gn9ecopOBqTW2cs7-kFXda5BtuOYaalru70kjzzZi746nGek--fPn67vOpuvny-vry46SzvWe24PahBMqGASc9gsmJwIIU1wno1SnbwxlghuZQO7SBAemBeCc5Fb5H3IM7J2-3ubU6_VyxVL6FYnGcTMa1FC5imEZTox4b2G9o6lZLR69scltZdM9APqvVRb6r1g2q9qW6xN48f1sOC7l_or9sGfNgAbD3vAmZdbMBo0YXmuGqXwv8__AFhY5Jv</recordid><startdate>202411</startdate><enddate>202411</enddate><creator>Xu, Ming-hong</creator><creator>Dou, Jian-ping</creator><creator>Guo, Mo-han</creator><creator>Yi, Wen-qi</creator><creator>Han, Zhi-yu</creator><creator>Liu, Fang-yi</creator><creator>Yu, Jie</creator><creator>Cheng, Zhi-gang</creator><creator>Yu, Xiao-ling</creator><creator>Wang, Hui</creator><creator>Bai, Nan</creator><creator>Wang, Shu-rong</creator><creator>Yu, Ming-an</creator><creator>Liang, Ping</creator><creator>Chen, Lei</creator><general>Elsevier B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>202411</creationdate><title>Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study</title><author>Xu, Ming-hong ; Dou, Jian-ping ; Guo, Mo-han ; Yi, Wen-qi ; Han, Zhi-yu ; Liu, Fang-yi ; Yu, Jie ; Cheng, Zhi-gang ; Yu, Xiao-ling ; Wang, Hui ; Bai, Nan ; Wang, Shu-rong ; Yu, Ming-an ; Liang, Ping ; Chen, Lei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c241t-2cb765137015f109c36d053ca3cf7851bfaac35255dec6305f01f732234ce2403</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ablation Techniques - adverse effects</topic><topic>Ablation Techniques - methods</topic><topic>Adult</topic><topic>Female</topic><topic>Hoarseness - etiology</topic><topic>Humans</topic><topic>Male</topic><topic>Microwave ablation</topic><topic>Microwaves - adverse effects</topic><topic>Microwaves - therapeutic use</topic><topic>Middle Aged</topic><topic>Recurrent laryngeal nerve</topic><topic>Recurrent Laryngeal Nerve Injuries - etiology</topic><topic>Retrospective Studies</topic><topic>Risk factor</topic><topic>Risk Factors</topic><topic>Thyroid nodule</topic><topic>Thyroid Nodule - pathology</topic><topic>Thyroid Nodule - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xu, Ming-hong</creatorcontrib><creatorcontrib>Dou, Jian-ping</creatorcontrib><creatorcontrib>Guo, Mo-han</creatorcontrib><creatorcontrib>Yi, Wen-qi</creatorcontrib><creatorcontrib>Han, Zhi-yu</creatorcontrib><creatorcontrib>Liu, Fang-yi</creatorcontrib><creatorcontrib>Yu, Jie</creatorcontrib><creatorcontrib>Cheng, Zhi-gang</creatorcontrib><creatorcontrib>Yu, Xiao-ling</creatorcontrib><creatorcontrib>Wang, Hui</creatorcontrib><creatorcontrib>Bai, Nan</creatorcontrib><creatorcontrib>Wang, Shu-rong</creatorcontrib><creatorcontrib>Yu, Ming-an</creatorcontrib><creatorcontrib>Liang, Ping</creatorcontrib><creatorcontrib>Chen, Lei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Radiotherapy and oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xu, Ming-hong</au><au>Dou, Jian-ping</au><au>Guo, Mo-han</au><au>Yi, Wen-qi</au><au>Han, Zhi-yu</au><au>Liu, Fang-yi</au><au>Yu, Jie</au><au>Cheng, Zhi-gang</au><au>Yu, Xiao-ling</au><au>Wang, Hui</au><au>Bai, Nan</au><au>Wang, Shu-rong</au><au>Yu, Ming-an</au><au>Liang, Ping</au><au>Chen, Lei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study</atitle><jtitle>Radiotherapy and oncology</jtitle><addtitle>Radiother Oncol</addtitle><date>2024-11</date><risdate>2024</risdate><volume>200</volume><spage>110516</spage><pages>110516-</pages><artnum>110516</artnum><issn>0167-8140</issn><issn>1879-0887</issn><eissn>1879-0887</eissn><abstract>•Clinicians should pay attention to several influencing factors for RLN injury.•Safe TEG-D thresholds were 2.2 mm for benign nodules and 4.9 mm for malignant ones.•TEG-D was an independent risk factor for recovery time of hoarseness.
This study aimed to investigate the risk factors for recurrent laryngeal nerve (RLN) injury after microwave ablation (MWA) of thyroid nodules and to identify factors influencing the recovery time of post-procedure hoarseness.
We retrospectively analyzed data from patients who underwent MWA for thyroid nodules at five hospitals between November 2018 and July 2022. Patients were divided into malignant and benign nodule groups. Variables analyzed included nodule size and location, the shortest distance from nodules to the thyroid capsule and tracheoesophageal groove (TEG-D), and ablation parameters. Univariate and multivariate analyses were performed to identify risk factors. Kaplan-Meier and Cox analyses were used to evaluate the recovery time of hoarseness after MWA.
The study included 1,216 patients (mean age 44 ± 12 [SD] years; 901 women) with 602 malignant nodules and 614 benign nodules. The posterior capsule distance (PCD) and TEG-D were identified as independent influencing factors for hoarseness in all patients (P = 0.014, OR = 0.068; P < 0.001, OR = 0.005; AUC = 0.869). TEG-D was a significant risk factor for hoarseness, with safe thresholds identified at 4.9 mm for malignant nodules and 2.2 mm for benign nodules. Among patients who developed hoarseness, those in the close-distance group (TEG-D≤2 mm) had a longer recovery time compared to the distant-distance group. TEG-D was an independent factor influencing recovery time (P = 0.008, HR = 11.204).
Clinicians should consider several factors, particularly TEG-D and PCD, when assessing the risk of RLN injury before MWA. TEG-D was a vital independent factor influencing recovery time.
Clinicians should pay attention to several influencing factors for RLN injury before MWA and TEG-D was an independent influencing factor for recovery time of hoarseness after MWA.</abstract><cop>Ireland</cop><pub>Elsevier B.V</pub><pmid>39216824</pmid><doi>10.1016/j.radonc.2024.110516</doi></addata></record> |
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| subjects | Ablation Techniques - adverse effects Ablation Techniques - methods Adult Female Hoarseness - etiology Humans Male Microwave ablation Microwaves - adverse effects Microwaves - therapeutic use Middle Aged Recurrent laryngeal nerve Recurrent Laryngeal Nerve Injuries - etiology Retrospective Studies Risk factor Risk Factors Thyroid nodule Thyroid Nodule - pathology Thyroid Nodule - surgery |
| title | Risk factors for recurrent laryngeal nerve injury in microwave ablation of thyroid nodules: A multicenter study |
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