Development of an AIE-active fluorescent probe for the simultaneous detection of Al3+ and viscosity and imaging in Alzheimer’s disease model

• Published in: Bioorganic chemistry 2024-11, Vol.152, p.107768, Article 107768
• Main Authors: Li, Na-Na, Lin, Wan-Ying, Wei, Ying-Ting, Jin, Zhan-Bin, Gu, Jian-Xia, Li, Hai-long, Ren, Hai-Xian, Xing, Zhi-Yong, Zong, Zi-Ao
• Format: Article
• Language: English
• Subjects: Aggregation-Induced Emission (AIE); Al3; Alzheimer’s disease (AD); Dual response; Viscosity
• ISSN: 0045-2068; 1090-2120; 1090-2120
• DOI: 10.1016/j.bioorg.2024.107768

[Display omitted] •The AIE probe YM2T was respond to Al3+ by fluorescence colormetric and viscosity by fluorescence “turn on” modes.•The probe YM2T could monitor Al3+ and viscosity in cells through blue and green fluorescent channel imaging, respectively.•The probe YM2T was used to image mice with AD. Alzheimer’s disease is associated both with imbalances in Al3+ production and changes in viscosity in cells. Their simultaneous measurement could therefore provide valuable insights into Alzheimer’s disease pathology. Their simultaneous measurement would therefore be of great value in investigating the pathological mechanism of Alzheimer’s disease. We designed a fluorescent probe YM2T with AIE effect that is capable of selectively responding to Al3+ by fluorescence colormetrics and to viscosity by fluorescence “turn on” modes. Additionally, Al3+ and viscosity were simultaneously detected in PC12 cells using the low cytotoxic probe YM2T via blue and green fluorescence channels. More importantly, the YM2T probe was used to image mice with AD. Hence, the YM2T probe shows potential as a useful molecular instrument for studying the pathological impact of Al3+ and viscosity.