Adjuvant therapy with zinc supplementation; anti-inflammatory and anti-oxidative role in multiple myeloma patients receiving autologous hematopoietic stem cell transplantation: a randomized controlled clinical trial

Multiple myeloma (MM) patients are often accompanied by heightened levels of oxidative stress, even following bone marrow transplantation. Trace mineral supplements have been found to regulate and inhibit the activity of oxidative radicals and inflammatory factors, which are involved in the pathogen...

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Bibliographic Details
Published in:Biometals 2024-12, Vol.37 (6), p.1609-1627
Main Authors: Jahankhani, Kasra, Taghipour, Niloofar, Nikoonezhad, Maryam, Behboudi, Hossein, Mehdizadeh, Mahshid, Kadkhoda, Dariush, Hajifathali, Abbas, Mosaffa, Nariman
Format: Article
Language:English
Subjects:
Adult
Aged
Anti-Inflammatory Agents - administration & dosage
Anti-Inflammatory Agents - therapeutic use
Antioxidants - administration & dosage
Biochemistry
Biomarkers
Biomedical and Life Sciences
Bone marrow
Bone marrow transplantation
Cell Biology
Chemotherapy
Clinical trials
CYBB protein
Dietary Supplements
Female
Genes
Hematopoietic Stem Cell Transplantation - adverse effects
Hematopoietic stem cells
Humans
Inflammation
Life Sciences
Male
Medicine/Public Health
Microbiology
Middle Aged
Multiple myeloma
Multiple Myeloma - drug therapy
Multiple Myeloma - therapy
Oxidative stress
Oxidative Stress - drug effects
Pathogenesis
Pharmacology/Toxicology
Placebos
Plant Physiology
Stem cell transplantation
Stem cells
Superoxide dismutase
Trace minerals
Transplantation
Transplantation, Autologous
Tumor necrosis factor-α
Zinc
Zinc - administration & dosage
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Summary:Multiple myeloma (MM) patients are often accompanied by heightened levels of oxidative stress, even following bone marrow transplantation. Trace mineral supplements have been found to regulate and inhibit the activity of oxidative radicals and inflammatory factors, which are involved in the pathogenesis of MM. The study sought to evaluate the effectiveness of the supplementation by analyzing changes in oxidative, anti-oxidative, and inflammation markers. Patients were randomly assigned to a zinc or placebo group, with the former receiving 30 mg of zinc or placebo tablets daily for 1 month. Blood samples were collected from the patients on the day of transplantation, 15 days, and 30 days post-transplantation. Real-time PCR was employed to measure the expression of oxidative/antioxidative genes. Furthermore, the protein level of oxidative markers in serum samples was assessed. Finally, serum TNF-α concentrations were measured using the ELISA technique. The expression levels of SOD1, SOD2, and NRF2 genes were significantly higher on days 15 and 30 compared to the control group (P 
ISSN:0966-0844
1572-8773
1572-8773
DOI:10.1007/s10534-024-00630-0