Heart failure biomarkers and prediction of early left ventricle remodeling after acute coronary syndromes

[Display omitted] •We compared serum concentrations of 6 biomarkers in patients admitted for acute coronary syndrome or heart failure vs. controls.•NT-pro BNP levels were positively correlated with CA-125, ST2 and galectin-3.•CA125 emerged as the single biomarker associated with left ventricle remod...

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Published in:Clinical biochemistry 2024-10, Vol.131-132, p.110814, Article 110814
Main Authors: Cordero, Alberto, Velasco, Irene, Flores, Emilio, López-Ayala, José Mª, Sánchez-Munuera, Sonia, Muñoz-Villalba, Mª Pilar, Selva-Mora, Alejandro, Galán-Giménez, Francisco, de la Espriella, Rafael, Nuñez, Julio
Format: Article
Language:English
Subjects:
Acute coronary syndromes
Biomarkers
CA-125
Cardiac remodeling
Heart failure development
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Summary:[Display omitted] •We compared serum concentrations of 6 biomarkers in patients admitted for acute coronary syndrome or heart failure vs. controls.•NT-pro BNP levels were positively correlated with CA-125, ST2 and galectin-3.•CA125 emerged as the single biomarker associated with left ventricle remodeling.•No other biomarker predicted changes in EDV or LVEF. Several biomarkers are characteristically elevated in patients with acute heart failure (AHF). Our hypothesis was they could predict early changes in left ventricular (LV) characteristics in acute coronary syndrome (ACS) patients. The objective of this study was two-fold: a) compare circulating concentrations of NT-pro BNP, CA-125, ST2, galectin-3 and pro-adrenomedullin among 4 groups of individuals (healthy controls; patients with ACS without AHF; patients with ACS and AHF and patients admitted for AHF); and b) evaluate whether these biomarkers predict adverse LV remodeling and ejection fraction changes in ACS. 6 biomarkers (NT-pro BNP, CA-125, ST2, galectin-3, pro-adrenomedullin and C-reactive) were measured within the first 48 h of admission. Echocardiograms were performed during admission and at 3 months. Variables associated with LV end-diastolic volume (EDV) and ejection fraction (LVEF) change were assessed by multivariate linear regression. We analyzed 51 patients with ACS, 16 with AHF and, 20 healthy controls. NT-pro BNP and ST2 concentrations were elevated at similar values in patients admitted for AHF and ACS complicated with HF but CA-125 concentrations were higher in AHF patients. NT-pro BNP concentrations were positively correlated with CA-125 (rho = 0.58; p 
ISSN:0009-9120
1873-2933
1873-2933
DOI:10.1016/j.clinbiochem.2024.110814