QRAGE—Simultaneous multiparametric quantitative MRI of water content, T1, T2, and magnetic susceptibility at ultrahigh field strength

Purpose To introduce quantitative rapid gradient‐echo (QRAGE), a novel approach for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength. Methods QRAGE leverages a newly developed multi‐echo MPnRAG...

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Bibliographic Details
Published in:Magnetic resonance in medicine 2025-01, Vol.93 (1), p.228-244
Main Authors: Zimmermann, Markus, Abbas, Zaheer, Sommer, Yannic, Lewin, Alexander, Ramkiran, Shukti, Felder, Jörg, Worthoff, Wieland A., Oros‐Peusquens, Ana‐Maria, Yun, Seong Dae, Shah, N. Jon
Format: Article
Language:English
Subjects:
Brain
Brain mapping
Field strength
Image acquisition
Image contrast
Image reconstruction
In vivo methods and tests
Knowledge representation
Magnetic permeability
Magnetic resonance imaging
Magnetic susceptibility
magnetization‐prepared multi‐echo gradient‐echo
Mapping
Medical imaging
model‐based iterative reconstruction
Moisture content
Neuroimaging
Parameters
quantitative MRI
simultaneous multiparameter mapping
structured low‐rank matrix
ultrahigh field strength
Water content
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Summary:Purpose To introduce quantitative rapid gradient‐echo (QRAGE), a novel approach for the simultaneous mapping of multiple quantitative MRI parameters, including water content, T1, T2*, and magnetic susceptibility at ultrahigh field strength. Methods QRAGE leverages a newly developed multi‐echo MPnRAGE sequence, facilitating the acquisition of 171 distinct contrast images across a range of TI and TE points. To maintain a short acquisition time, we introduce MIRAGE2, a novel model‐based reconstruction method that exploits prior knowledge of temporal signal evolution, represented as damped complex exponentials. MIRAGE2 minimizes local Block‐Hankel and Casorati matrices. Parameter maps are derived from the reconstructed contrast images through postprocessing steps. We validate QRAGE through extensive simulations, phantom studies, and in vivo experiments, demonstrating its capability for high‐precision imaging. Results In vivo brain measurements show the promising performance of QRAGE, with test–retest SDs and deviations from reference methods of
ISSN:0740-3194
1522-2594
1522-2594
DOI:10.1002/mrm.30272