Muscle-enriched microRNA-486-mediated regulation of muscular atrophy and exercise

• Published in: Journal of physiology and biochemistry 2024-11, Vol.80 (4), p.795-809
• Main Authors: Qiu, Dayong, Zhang, Yan, Ni, Pinshi, Wang, Zhuangzhi, Yang, Luodan, Li, Fanghui
• Format: Article
• Language: English
• Subjects: 1-Phosphatidylinositol 3-kinase; Aging; AKT protein; Animal Physiology; Animals; Atrophy; Biomedical and Life Sciences; Biomedicine; Cell growth; Conserved sequence; Disorders; Enrichment; Environmental effects; Exercise; Homeostasis; Human Physiology; Humans; Microgravity; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Muscle Development; Muscle, Skeletal - metabolism; Muscles; Muscular Atrophy - genetics; Muscular Atrophy - metabolism; Muscular diseases; Musculoskeletal system; Myogenesis; Neuromuscular diseases; Physiological effects; Protein biosynthesis; Protein synthesis; Proteins; PTEN protein; Review; Ribonucleic acid; RNA; Sarcopenia; Sarcopenia - genetics; Sarcopenia - metabolism; Sarcopenia - pathology; Sarcopenia - prevention & control; Signal Transduction; Skeletal muscle; Therapeutic targets
• ISSN: 1138-7548; 1877-8755; 1877-8755
• DOI: 10.1007/s13105-024-01043-w

The objectives of this review were to understand the impact of microRNA-486 on myogenesis and muscle atrophy, and the change of microRNA-486 following exercise, and provide valuable information for improving muscle atrophy based on exercise intervention targeting microRNA-486. Muscle-enriched microRNAs (miRNAs), also referred to as myomiRs, control various processes in skeletal muscles, from myogenesis and muscle homeostasis to different responses to environmental stimuli such as exercise. MicroRNA-486 is a miRNA in which a stem-loop sequence is embedded within the ANKYRIN1 (ANK1) locus and is strictly conserved across mammals. MicroRNA-486 is involved in the development of muscle atrophy caused by aging, immobility, prolonged exposure to microgravity, or muscular and neuromuscular disorders. PI3K/AKT signaling is a positive pathway, as it increases muscle mass by increasing protein synthesis and decreasing protein degradation. MicroRNA-486 can activate this pathway by inhibiting phosphatase and tensin homolog (PTEN), it may also indirectly inhibit the HIPPO signaling pathway to promote cell growth. Exercises regulate microRNA-486 expression both in blood and muscle. This review focused on the recent elucidation of sarcopenia regulation by microRNA-486 and its effects on pathological states, including primary muscular disease, secondary muscular disorders, and age-related sarcopenia. Additionally, the role of exercise in regulating skeletal muscle-enriched microRNA-486 was highlighted, along with its physiological significance. Growing evidence indicates that microRNA-486 significantly impacts the development of muscle atrophy. MicroRNA-486 has great potential to become a therapeutic target for improving muscle atrophy through exercise intervention. Key points 1. MiR-486 is closely related to various muscle atrophy diseases. 2. Effects of different exercise types on expression of microRNA-486 are highlighted. 3. Exercise may an effective therapy for skeletal muscle atrophy through the microRNA-486 pathway.