Sheep and goats as reservoirs of colistin-resistant E. coli: first detection of ETEC ST10 and E. coli ST6396 mcr-1 positive strains in North Africa

This study aimed to screen and characterize colistin-resistant strains isolated from different livestock species in Algeria, including sheep, goats, and dromedaries. A total of 197 rectal and nasal swabs were screened for colistin-resistant Gram-negative bacilli. Twenty one isolates were selected, i...

Full description

Saved in:
Bibliographic Details
Published in:Journal of applied microbiology 2024-09, Vol.135 (9)
Main Authors: Boukli-Hacene, Fella, Djouadi, Lydia Neïla, Raddaoui, Anis, Hachem, Yousra, Boumerdassi, Hanane, Achour, Wafa, Nateche, Farida
Format: Article
Language:English
Subjects:
Africa, Northern
Algeria
Animals
Anti-Bacterial Agents - pharmacology
Colistin - pharmacology
Disease Reservoirs - microbiology
Drug Resistance, Bacterial - genetics
Drug Resistance, Multiple, Bacterial - genetics
Enterotoxigenic Escherichia coli - drug effects
Enterotoxigenic Escherichia coli - genetics
Enterotoxigenic Escherichia coli - isolation & purification
Escherichia coli - drug effects
Escherichia coli - genetics
Escherichia coli - isolation & purification
Escherichia coli Infections - microbiology
Escherichia coli Infections - veterinary
Escherichia coli Proteins - genetics
Goats
Microbial Sensitivity Tests
Sheep
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:This study aimed to screen and characterize colistin-resistant strains isolated from different livestock species in Algeria, including sheep, goats, and dromedaries. A total of 197 rectal and nasal swabs were screened for colistin-resistant Gram-negative bacilli. Twenty one isolates were selected, identified, and their antibiotic resistance was phenotypically and genotypically characterized. The majority (15/21) were affiliated to Escherichia coli, from which 4 strains isolated from sheep (n = 2) and goats (n = 2) and belonging to phylogroup A and ST10 and ST6396 lineages, respectively, carried the mcr-1 gene. The remaining isolates were identified as belonging to the following genera: Raoultella, Enterobacter, Klebsiella, and Pseudomonas. This study highlights the presence of virulent and multiresistant Gram-negative bacilli in farm animals, increasing the risk of transmitting potentially fatal infections to humans.
ISSN:1365-2672
1365-2672
DOI:10.1093/jambio/lxae227