Long-term acclimation to organic carbon enhances the production of loliolide from Scenedesmus deserticola

[Display omitted] •Acclimation of Scenedesmus deserticola to glucose-rich condition was demonstrated.•Long-term acclimation led to the selection of Scenedesmus deserticola HS4.•S. deserticola HS4 exhibited an increased heterotrophic capability.•2- to 10-fold increase in loliolide productivity was ob...

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Bibliographic Details
Published in:Bioresource technology 2024-11, Vol.412, p.131408, Article 131408
Main Authors: Cho, Dae-Hyun, Yun, Jin-Ho, Choi, Dong-Yoon, Heo, Jina, Kim, Eun Kyung, Ha, Juran, Yoo, Chan, Choi, Hong Il, Lee, Yong Jae, Kim, Hee-Sik
Format: Article
Language:English
Subjects:
Acclimation
agar
commercialization
glucose
Heterotrophy
Loliolide
microalgae
organic carbon
Scenedesmus
Scenedesmus deserticola HS4
technology
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Summary:[Display omitted] •Acclimation of Scenedesmus deserticola to glucose-rich condition was demonstrated.•Long-term acclimation led to the selection of Scenedesmus deserticola HS4.•S. deserticola HS4 exhibited an increased heterotrophic capability.•2- to 10-fold increase in loliolide productivity was observed in S. deserticola HS4.•Fed-batch cultivation led to further improvement in loliolide productivity. Production of functional biocompounds from microalgae has garnered interest from different industrial sectors; however, their overall productivity must be substantially improved for commercialization. Herein, long-term acclimation of Scenedesmus deserticola was conducted using glucose as an organic carbon source to enhance its heterotrophic capabilities and the production potential of loliolide. A year-long acclimation on agar plates led to the selection of S. deserticola HS4, which exhibited at least 2-fold increase in loliolide production potential; S. deserticola HS4 was subjected to further screening of its cultivation conditions and fed-batch cultivation was subsequently performed in liter-scale reactors. While S. deserticola HS4 exhibited shifts in cellular morphology and biochemical composition, the results suggested a substantial increase in its loliolide productivity regardless of trophic modes. Collectively, these results highlight the potential of long-term acclimation as an effective strategy for improving microalgal crops to align with industrial production practices.
ISSN:0960-8524
1873-2976
1873-2976
DOI:10.1016/j.biortech.2024.131408