Incidence and risk factors of antituberculosis drug-induced liver injury in India: A systematic review and meta-analysis

Antituberculosis drug-induced liver injury (ATDILI) is a significant problem of tuberculosis treatment. This systematic review and meta‑analysis aimed at evaluating the incidence and risk factors of ATDILI in adult patients with tuberculosis in India. Five electronic databases were searched comprehe...

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Bibliographic Details
Published in:Indian journal of gastroenterology 2024-09
Main Authors: Kumar, Ramesh, Kumar, Abhishek, Patel, Rishabh, Prakash, Sabbu Surya, Kumar, Sudhir, Surya, Himanshu, Marrapu, Sudheer
Format: Article
Language:English
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Summary:Antituberculosis drug-induced liver injury (ATDILI) is a significant problem of tuberculosis treatment. This systematic review and meta‑analysis aimed at evaluating the incidence and risk factors of ATDILI in adult patients with tuberculosis in India. Five electronic databases were searched comprehensively for studies on Indian adult patients with tuberculosis investigating the incidence and/or risk factors of ATDILI. The relevant data was pooled in a random or fixed-effect model to calculate the pooled incidence with a 95% confidence interval (CI), standardized mean difference (MD) or odds ratio (OR). Following the screening of 3221 records, 43 studies with 12,041 tuberculosis patients were finally included. Based on the random effect model, the pooled incidence of ATDILI was 12.6% (95% CI, 9.9-15.3%, p 
ISSN:0254-8860
0975-0711
0975-0711
DOI:10.1007/s12664-024-01643-w