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Biochemical profile of renal amyloidosis in a Latin American cohort
Background Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described. Methods A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between Januar...
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| Published in: | Journal of nephrology 2024-11, Vol.37 (8), p.2351-2354 |
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| container_title | Journal of nephrology |
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| creator | Carretero, Marcelina Minoletti, Sofia Antonella Aguirre, María Adela Nucifora, Elsa Mercedes Sáez, María Sáez Martínez, María Lourdes Posadas |
| description | Background
Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described.
Methods
A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between January 1, 2010, and April 30, 2022 at the Hospital Italiano de Buenos Aires. Participants were retrospectively identified from the Institutional Amyloidosis Registry. Patients diagnosed with AL amyloidosis and evidence of renal involvement were included. Individuals with other types of amyloidosis were excluded. The selection process involved a thorough review of medical records and registry data to ensure accurate identification and inclusion of eligible participants.
Results
Seventy-seven patients were included. At diagnosis, 90% of the subjects had proteinuria, with a median of 4.3 g/24 h, 61% had renal failure, and 47% presented nephrotic syndrome. Semi-automated urinary electrophoresis revealed 55% with non-selective and 21% with moderately selective glomerular proteinuria. Urine immunofixation indicated 64% with lambda monoclonal free light chains and 12% with kappa. Serum immunofixation demonstrated 48% with lambda monoclonal type and 25% with lambda IgG. At the time of diagnosis of AL amyloidosis, the median age was 66 years (IQR 53–72) and 49% were men. In addition to kidney involvement, other organs were also affected: heart in 53%, gastrointestinal system in 19%, peripheral nervous system in 16%, and liver in 16% of patients.
Conclusion
Our study provides a biochemical profile in renal amyloidosis due to immunoglobulin light chains in a Latin American population. Proteinuria emerged as the most common finding in this cohort with frequent multiorgan involvement.
Graphical abstract |
| doi_str_mv | 10.1007/s40620-024-02046-y |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_3100275648</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3100275648</sourcerecordid><originalsourceid>FETCH-LOGICAL-c228t-b397260c01385b563a28c27be7d736ebdc8d63b56bfdae4bcd98c1bac53dc5d43</originalsourceid><addsrcrecordid>eNp9kDtPwzAUhS0EoqXwBxiQR5aAY8d2MpaIl1SJBWbLr1BXSVzsZMi_x5CCmBiu7r2-5xxZHwCXObrJEeK3sUAMowzhIhUqWDYdgWXO08oQrY7_zAtwFuMOIUwpLk7BglQY04pXS1DfOa-3tnNatnAffONaC30Dg-3Tg-ym1jvjo4vQ9VDCjRxSX3c2JEMPtd_6MJyDk0a20V4c-gq8Pdy_1k_Z5uXxuV5vMo1xOWSKVBwzpFFOSqooIxKXGnNlueGEWWV0aRhJB9UYaQulTVXqXElNidHUFGQFrufc9M-P0cZBdC5q27ayt36MgiQqmFNWlEmKZ6kOPsZgG7EPrpNhEjkSX_DEDE8keOIbnpiS6eqQP6rOml_LD60kILMgplP_boPY-TEkUPG_2E87O3r0</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3100275648</pqid></control><display><type>article</type><title>Biochemical profile of renal amyloidosis in a Latin American cohort</title><source>Springer Nature</source><creator>Carretero, Marcelina ; Minoletti, Sofia Antonella ; Aguirre, María Adela ; Nucifora, Elsa Mercedes ; Sáez, María Sáez ; Martínez, María Lourdes Posadas</creator><creatorcontrib>Carretero, Marcelina ; Minoletti, Sofia Antonella ; Aguirre, María Adela ; Nucifora, Elsa Mercedes ; Sáez, María Sáez ; Martínez, María Lourdes Posadas</creatorcontrib><description>Background
Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described.
Methods
A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between January 1, 2010, and April 30, 2022 at the Hospital Italiano de Buenos Aires. Participants were retrospectively identified from the Institutional Amyloidosis Registry. Patients diagnosed with AL amyloidosis and evidence of renal involvement were included. Individuals with other types of amyloidosis were excluded. The selection process involved a thorough review of medical records and registry data to ensure accurate identification and inclusion of eligible participants.
Results
Seventy-seven patients were included. At diagnosis, 90% of the subjects had proteinuria, with a median of 4.3 g/24 h, 61% had renal failure, and 47% presented nephrotic syndrome. Semi-automated urinary electrophoresis revealed 55% with non-selective and 21% with moderately selective glomerular proteinuria. Urine immunofixation indicated 64% with lambda monoclonal free light chains and 12% with kappa. Serum immunofixation demonstrated 48% with lambda monoclonal type and 25% with lambda IgG. At the time of diagnosis of AL amyloidosis, the median age was 66 years (IQR 53–72) and 49% were men. In addition to kidney involvement, other organs were also affected: heart in 53%, gastrointestinal system in 19%, peripheral nervous system in 16%, and liver in 16% of patients.
Conclusion
Our study provides a biochemical profile in renal amyloidosis due to immunoglobulin light chains in a Latin American population. Proteinuria emerged as the most common finding in this cohort with frequent multiorgan involvement.
Graphical abstract</description><identifier>ISSN: 1724-6059</identifier><identifier>EISSN: 1724-6059</identifier><identifier>DOI: 10.1007/s40620-024-02046-y</identifier><identifier>PMID: 39225979</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Aged ; Amyloidosis - diagnosis ; Amyloidosis - epidemiology ; Argentina - epidemiology ; Biomarkers - blood ; Biomarkers - urine ; Cross-Sectional Studies ; Female ; Humans ; Immunoglobulin kappa-Chains - analysis ; Immunoglobulin kappa-Chains - blood ; Immunoglobulin kappa-Chains - urine ; Immunoglobulin lambda-Chains - blood ; Immunoglobulin Light-chain Amyloidosis - blood ; Immunoglobulin Light-chain Amyloidosis - diagnosis ; Immunoglobulin Light-chain Amyloidosis - epidemiology ; Immunoglobulin Light-chain Amyloidosis - urine ; Kidney Diseases - diagnosis ; Kidney Diseases - epidemiology ; Kidney Diseases - etiology ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Nephrology ; Nephrology Crossing Borders ; Nephrotic Syndrome - urine ; Proteinuria - etiology ; Registries ; Retrospective Studies ; Urology</subject><ispartof>Journal of nephrology, 2024-11, Vol.37 (8), p.2351-2354</ispartof><rights>The Author(s) under exclusive licence to Italian Society of Nephrology 2024</rights><rights>2024. The Author(s) under exclusive licence to Italian Society of Nephrology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c228t-b397260c01385b563a28c27be7d736ebdc8d63b56bfdae4bcd98c1bac53dc5d43</cites><orcidid>0000-0003-2259-5626 ; 0000-0001-9690-2284 ; 0000-0003-2177-7727 ; 0000-0002-7905-7549 ; 0000-0003-1403-7069</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39225979$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Carretero, Marcelina</creatorcontrib><creatorcontrib>Minoletti, Sofia Antonella</creatorcontrib><creatorcontrib>Aguirre, María Adela</creatorcontrib><creatorcontrib>Nucifora, Elsa Mercedes</creatorcontrib><creatorcontrib>Sáez, María Sáez</creatorcontrib><creatorcontrib>Martínez, María Lourdes Posadas</creatorcontrib><title>Biochemical profile of renal amyloidosis in a Latin American cohort</title><title>Journal of nephrology</title><addtitle>J Nephrol</addtitle><addtitle>J Nephrol</addtitle><description>Background
Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described.
Methods
A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between January 1, 2010, and April 30, 2022 at the Hospital Italiano de Buenos Aires. Participants were retrospectively identified from the Institutional Amyloidosis Registry. Patients diagnosed with AL amyloidosis and evidence of renal involvement were included. Individuals with other types of amyloidosis were excluded. The selection process involved a thorough review of medical records and registry data to ensure accurate identification and inclusion of eligible participants.
Results
Seventy-seven patients were included. At diagnosis, 90% of the subjects had proteinuria, with a median of 4.3 g/24 h, 61% had renal failure, and 47% presented nephrotic syndrome. Semi-automated urinary electrophoresis revealed 55% with non-selective and 21% with moderately selective glomerular proteinuria. Urine immunofixation indicated 64% with lambda monoclonal free light chains and 12% with kappa. Serum immunofixation demonstrated 48% with lambda monoclonal type and 25% with lambda IgG. At the time of diagnosis of AL amyloidosis, the median age was 66 years (IQR 53–72) and 49% were men. In addition to kidney involvement, other organs were also affected: heart in 53%, gastrointestinal system in 19%, peripheral nervous system in 16%, and liver in 16% of patients.
Conclusion
Our study provides a biochemical profile in renal amyloidosis due to immunoglobulin light chains in a Latin American population. Proteinuria emerged as the most common finding in this cohort with frequent multiorgan involvement.
Graphical abstract</description><subject>Aged</subject><subject>Amyloidosis - diagnosis</subject><subject>Amyloidosis - epidemiology</subject><subject>Argentina - epidemiology</subject><subject>Biomarkers - blood</subject><subject>Biomarkers - urine</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunoglobulin kappa-Chains - analysis</subject><subject>Immunoglobulin kappa-Chains - blood</subject><subject>Immunoglobulin kappa-Chains - urine</subject><subject>Immunoglobulin lambda-Chains - blood</subject><subject>Immunoglobulin Light-chain Amyloidosis - blood</subject><subject>Immunoglobulin Light-chain Amyloidosis - diagnosis</subject><subject>Immunoglobulin Light-chain Amyloidosis - epidemiology</subject><subject>Immunoglobulin Light-chain Amyloidosis - urine</subject><subject>Kidney Diseases - diagnosis</subject><subject>Kidney Diseases - epidemiology</subject><subject>Kidney Diseases - etiology</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Nephrology</subject><subject>Nephrology Crossing Borders</subject><subject>Nephrotic Syndrome - urine</subject><subject>Proteinuria - etiology</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Urology</subject><issn>1724-6059</issn><issn>1724-6059</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kDtPwzAUhS0EoqXwBxiQR5aAY8d2MpaIl1SJBWbLr1BXSVzsZMi_x5CCmBiu7r2-5xxZHwCXObrJEeK3sUAMowzhIhUqWDYdgWXO08oQrY7_zAtwFuMOIUwpLk7BglQY04pXS1DfOa-3tnNatnAffONaC30Dg-3Tg-ym1jvjo4vQ9VDCjRxSX3c2JEMPtd_6MJyDk0a20V4c-gq8Pdy_1k_Z5uXxuV5vMo1xOWSKVBwzpFFOSqooIxKXGnNlueGEWWV0aRhJB9UYaQulTVXqXElNidHUFGQFrufc9M-P0cZBdC5q27ayt36MgiQqmFNWlEmKZ6kOPsZgG7EPrpNhEjkSX_DEDE8keOIbnpiS6eqQP6rOml_LD60kILMgplP_boPY-TEkUPG_2E87O3r0</recordid><startdate>20241101</startdate><enddate>20241101</enddate><creator>Carretero, Marcelina</creator><creator>Minoletti, Sofia Antonella</creator><creator>Aguirre, María Adela</creator><creator>Nucifora, Elsa Mercedes</creator><creator>Sáez, María Sáez</creator><creator>Martínez, María Lourdes Posadas</creator><general>Springer International Publishing</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0003-2259-5626</orcidid><orcidid>https://orcid.org/0000-0001-9690-2284</orcidid><orcidid>https://orcid.org/0000-0003-2177-7727</orcidid><orcidid>https://orcid.org/0000-0002-7905-7549</orcidid><orcidid>https://orcid.org/0000-0003-1403-7069</orcidid></search><sort><creationdate>20241101</creationdate><title>Biochemical profile of renal amyloidosis in a Latin American cohort</title><author>Carretero, Marcelina ; Minoletti, Sofia Antonella ; Aguirre, María Adela ; Nucifora, Elsa Mercedes ; Sáez, María Sáez ; Martínez, María Lourdes Posadas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c228t-b397260c01385b563a28c27be7d736ebdc8d63b56bfdae4bcd98c1bac53dc5d43</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Aged</topic><topic>Amyloidosis - diagnosis</topic><topic>Amyloidosis - epidemiology</topic><topic>Argentina - epidemiology</topic><topic>Biomarkers - blood</topic><topic>Biomarkers - urine</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Immunoglobulin kappa-Chains - analysis</topic><topic>Immunoglobulin kappa-Chains - blood</topic><topic>Immunoglobulin kappa-Chains - urine</topic><topic>Immunoglobulin lambda-Chains - blood</topic><topic>Immunoglobulin Light-chain Amyloidosis - blood</topic><topic>Immunoglobulin Light-chain Amyloidosis - diagnosis</topic><topic>Immunoglobulin Light-chain Amyloidosis - epidemiology</topic><topic>Immunoglobulin Light-chain Amyloidosis - urine</topic><topic>Kidney Diseases - diagnosis</topic><topic>Kidney Diseases - epidemiology</topic><topic>Kidney Diseases - etiology</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Nephrology</topic><topic>Nephrology Crossing Borders</topic><topic>Nephrotic Syndrome - urine</topic><topic>Proteinuria - etiology</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Carretero, Marcelina</creatorcontrib><creatorcontrib>Minoletti, Sofia Antonella</creatorcontrib><creatorcontrib>Aguirre, María Adela</creatorcontrib><creatorcontrib>Nucifora, Elsa Mercedes</creatorcontrib><creatorcontrib>Sáez, María Sáez</creatorcontrib><creatorcontrib>Martínez, María Lourdes Posadas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of nephrology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Carretero, Marcelina</au><au>Minoletti, Sofia Antonella</au><au>Aguirre, María Adela</au><au>Nucifora, Elsa Mercedes</au><au>Sáez, María Sáez</au><au>Martínez, María Lourdes Posadas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Biochemical profile of renal amyloidosis in a Latin American cohort</atitle><jtitle>Journal of nephrology</jtitle><stitle>J Nephrol</stitle><addtitle>J Nephrol</addtitle><date>2024-11-01</date><risdate>2024</risdate><volume>37</volume><issue>8</issue><spage>2351</spage><epage>2354</epage><pages>2351-2354</pages><issn>1724-6059</issn><eissn>1724-6059</eissn><abstract>Background
Two-thirds of patients with immunoglobulin light chain (AL) amyloidosis have renal involvement. The biochemical profile of kidney damage is poorly described.
Methods
A cross-sectional study was conducted involving patients diagnosed with AL amyloidosis and renal involvement between January 1, 2010, and April 30, 2022 at the Hospital Italiano de Buenos Aires. Participants were retrospectively identified from the Institutional Amyloidosis Registry. Patients diagnosed with AL amyloidosis and evidence of renal involvement were included. Individuals with other types of amyloidosis were excluded. The selection process involved a thorough review of medical records and registry data to ensure accurate identification and inclusion of eligible participants.
Results
Seventy-seven patients were included. At diagnosis, 90% of the subjects had proteinuria, with a median of 4.3 g/24 h, 61% had renal failure, and 47% presented nephrotic syndrome. Semi-automated urinary electrophoresis revealed 55% with non-selective and 21% with moderately selective glomerular proteinuria. Urine immunofixation indicated 64% with lambda monoclonal free light chains and 12% with kappa. Serum immunofixation demonstrated 48% with lambda monoclonal type and 25% with lambda IgG. At the time of diagnosis of AL amyloidosis, the median age was 66 years (IQR 53–72) and 49% were men. In addition to kidney involvement, other organs were also affected: heart in 53%, gastrointestinal system in 19%, peripheral nervous system in 16%, and liver in 16% of patients.
Conclusion
Our study provides a biochemical profile in renal amyloidosis due to immunoglobulin light chains in a Latin American population. Proteinuria emerged as the most common finding in this cohort with frequent multiorgan involvement.
Graphical abstract</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>39225979</pmid><doi>10.1007/s40620-024-02046-y</doi><tpages>4</tpages><orcidid>https://orcid.org/0000-0003-2259-5626</orcidid><orcidid>https://orcid.org/0000-0001-9690-2284</orcidid><orcidid>https://orcid.org/0000-0003-2177-7727</orcidid><orcidid>https://orcid.org/0000-0002-7905-7549</orcidid><orcidid>https://orcid.org/0000-0003-1403-7069</orcidid></addata></record> |
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| ispartof | Journal of nephrology, 2024-11, Vol.37 (8), p.2351-2354 |
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| source | Springer Nature |
| subjects | Aged Amyloidosis - diagnosis Amyloidosis - epidemiology Argentina - epidemiology Biomarkers - blood Biomarkers - urine Cross-Sectional Studies Female Humans Immunoglobulin kappa-Chains - analysis Immunoglobulin kappa-Chains - blood Immunoglobulin kappa-Chains - urine Immunoglobulin lambda-Chains - blood Immunoglobulin Light-chain Amyloidosis - blood Immunoglobulin Light-chain Amyloidosis - diagnosis Immunoglobulin Light-chain Amyloidosis - epidemiology Immunoglobulin Light-chain Amyloidosis - urine Kidney Diseases - diagnosis Kidney Diseases - epidemiology Kidney Diseases - etiology Male Medicine Medicine & Public Health Middle Aged Nephrology Nephrology Crossing Borders Nephrotic Syndrome - urine Proteinuria - etiology Registries Retrospective Studies Urology |
| title | Biochemical profile of renal amyloidosis in a Latin American cohort |
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